DUG2 glutamine amidotransferase subunit DUG2 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: DUG2
Official Full Name: glutamine amidotransferase subunit DUG2
Primary source: SGD:S000000485
Locus tag: YBR281C
See related: AllianceGenome:SGD:S000000485; FungiDB:YBR281C; VEuPathDB:YBR281C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables omega peptidase activity. Contributes to glutathione hydrolase activity. Involved in glutathione catabolic process. Located in cytoplasm and nuclear periphery. Part of glutathione hydrolase complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See DUG2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (764970..767606, complement)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dug2p and Dug3p were required together for the cleavage of glutathione into glutamate and Cys-Gly.
Title: Glutathione degradation by the alternative pathway (DUG pathway) in Saccharomyces cerevisiae is initiated by (Dug2p-Dug3p)2 complex, a novel glutamine amidotransferase (GATase) enzyme acting on glutathione.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables dipeptidase activity	IEA Inferred from Electronic Annotation more info
contributes_to glutathione hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables metallopeptidase activity	IEA Inferred from Electronic Annotation more info
enables omega peptidase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in glutathione catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutathione catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in glutathione catabolic process	IEA Inferred from Electronic Annotation more info
involved_in glutathione catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of glutathione hydrolase complex	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear periphery	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: glutamine amidotransferase subunit DUG2

NP_009840.3

Component of glutamine amidotransferase (GATase II); forms a complex with Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001134.8 Reference assembly

Range

764970..767606 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178629.3 → NP_009840.3 TPA: glutamine amidotransferase subunit DUG2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_009840.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VQS6, P38149

UniProtKB/TrEMBL

A6ZLL9, B3LMN2, D3UF28, N1P8V9

Conserved Domains (3) summary

sd00039
Location:23 → 60

7WD40; WD40 repeat [structural motif]

cd05677
Location:437 → 878

M20_dipept_like_DUG2_type; M20 Defective in Utilization of Glutathione-type peptidases containing WD repeats

cl29593
Location:19 → 336

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...