HTB2 histone H2B [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: HTB2
Official Full Name: histone H2B
Primary source: SGD:S000000098
Locus tag: YBL002W
See related: AllianceGenome:SGD:S000000098; FungiDB:YBL002W; VEuPathDB:YBL002W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable DNA binding activity. Predicted to be involved in chromatin organization. Part of replication fork protection complex. Orthologous to several human genes including H2BC5 (H2B clustered histone 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HTB2 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 1

Sequence:: Chromosome: II; NC_001134.8 (236492..236887)

Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001134.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Histone sumoylation promotes Set3 histone-deacetylase complex-mediated transcriptional regulation.
Title: Histone sumoylation promotes Set3 histone-deacetylase complex-mediated transcriptional regulation.
The histone modification domain of Paf1 complex subunit Rtf1 directly stimulates H2B ubiquitylation through an interaction with Rad6.
Title: The Histone Modification Domain of Paf1 Complex Subunit Rtf1 Directly Stimulates H2B Ubiquitylation through an Interaction with Rad6.
A role for the H2B nucleosome acidic patch in recruitment of histone modification machinery and maintenance of transcriptional integrity.
Title: The Nucleosome Acidic Patch Regulates the H2B K123 Monoubiquitylation Cascade and Transcription Elongation in Saccharomyces cerevisiae.
These results indicate that eukaryotic cells respond to RNAPII arrest by deubiquitylating H2B to coordinate DNA repair and RNAPII degradation.
Title: UV damage-induced RNA polymerase II stalling stimulates H2B deubiquitylation.
Data indicate that histone H2B repression (HBR) domain is important for FACT (consisting of Spt16/Pob3) histone chaperone activity.
Title: A highly conserved region within H2B is important for FACT to act on nucleosomes.
this study provides evidence that only small levels of H2BK123ub are necessary for full levels of H3K4 and H3K79 trimethylation in vivo and points to a possible role for Chd1 in positively regulating gene expression through promoting nucleosome reassembly coupled with H2B monoubiquitination.
Title: Codependency of H2B monoubiquitination and nucleosome reassembly on Chd1.
Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat.
Title: Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat.
Results describe a novel role for the H2B C-terminal helix in the trans-histone cross talk as a binding surface for Set1-COMPASS.
Title: Histone H2B C-terminal helix mediates trans-histone H3K4 methylation independent of H2B ubiquitination.
propose a structural model by which H2B R102 and K111 regulate the binding of the Sir complex to the nucleosome
Title: Novel functional residues in the core domain of histone H2B regulate yeast gene expression and silencing and affect the response to DNA damage.
Disruption of Lge1 abolished ubiquitylation of histone H2B on lysine 123 and H3 methylation on lysines 4 and 79
Title: A Bre1-associated protein, large 1 (Lge1), promotes H2B ubiquitylation during the early stages of transcription elongation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin organization	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	TAS Traceable Author Statement more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of replication fork protection complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: histone H2B

NP_009553.1

Histone H2B; core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates reassembly after DNA replication, transcriptional activation, meiotic DSB formation and H3 methylation