U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    IRC21 Irc21p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855095, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    IRC21
    Official Full Name
    Irc21p
    Primary source
    SGD:S000004677
    Locus tag
    YMR073C
    See related
    AllianceGenome:SGD:S000004677; FungiDB:YMR073C; VEuPathDB:YMR073C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable cytochrome-b5 reductase activity, acting on NAD(P)H and heme binding activity. Involved in DNA damage response. Located in cytoplasm. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CYB5R4 (cytochrome b5 reductase 4). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See IRC21 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (412268..412873, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Tvp18p Neighboring gene DNA-binding protein ABF2 Neighboring gene Sdd2p Neighboring gene Rco1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Dissection of DNA damage responses using multiconditional genetic interaction maps. Guénolé A, et al. Mol Cell, 2013 Jan 24. PMID 23273983, Free PMC Article
    2. Genome-wide requirements for resistance to functionally distinct DNA-damaging agents. Lee W, et al. PLoS Genet, 2005 Aug. PMID 16121259, Free PMC Article
    3. Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting recombination. Alvaro D, et al. PLoS Genet, 2007 Dec. PMID 18085829, Free PMC Article
    4. A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. Gallego O, et al. Mol Syst Biol, 2010 Nov 30. PMID 21119626, Free PMC Article
    5. PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response. Ferrari E, et al. Mol Cell, 2017 Jul 20. PMID 28648781, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cytochrome-b5 reductase activity, acting on NAD(P)H IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus HMP PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Irc21p
    NP_013789.1
    • hypothetical protein; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      412268..412873 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182571.1 → NP_013789.1  TPA: Irc21p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013789.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZP7, Q04772
      UniProtKB/TrEMBL
      B3LLW6, B5VPJ9, C7GL51, C8ZES5
      Conserved Domains (1) summary
      COG5274
      Location:30 → 199
      CYB5; Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04772.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools