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    PGA3 cytochrome-b5 reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854914, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PGA3
    Official Full Name
    cytochrome-b5 reductase
    Primary source
    SGD:S000004594
    Locus tag
    YML125C
    See related
    AllianceGenome:SGD:S000004594; FungiDB:YML125C; VEuPathDB:YML125C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    NQR1
    Summary
    Enables cytochrome-b5 reductase activity, acting on NAD(P)H. Involved in protein transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in breast cancer and methemoglobinemia. Orthologous to human CYB5R1 (cytochrome b5 reductase 1) and CYB5R3 (cytochrome b5 reductase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PGA3 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (20761..21699, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Rsc9p Neighboring gene hydroxymethylglutaryl-CoA synthase Neighboring gene alpha-tubulin TUB3 Neighboring gene ncRNA Neighboring gene phosphate transporter PHO84

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Jiménez-Hidalgo M, et al. Aging Cell, 2009 Apr. PMID 19239415, Free PMC Article
    2. A survey of essential gene function in the yeast cell division cycle. Yu L, et al. Mol Biol Cell, 2006 Nov. PMID 16943325, Free PMC Article
    3. Identification and characterization of protein interactions with the major Niemann-Pick type C disease protein in yeast reveals pathways of therapeutic potential. Hammond N, et al. Genetics, 2023 Aug 31. PMID 37440478, Free PMC Article
    4. Identification and Functional Testing of Novel Interacting Protein Partners for the Stress Sensors Wsc1p and Mid2p of Saccharomyces cerevisiae. Santiago-Cartagena E, et al. G3 (Bethesda), 2019 Apr 9. PMID 30733383, Free PMC Article
    5. ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology. Manford AG, et al. Dev Cell, 2012 Dec 11. PMID 23237950

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cytochrome-b5 reductase activity, acting on NAD(P)H IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytochrome-b5 reductase activity, acting on NAD(P)H IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytochrome-b5 reductase activity, acting on NAD(P)H IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ergosterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome-b5 reductase
    NP_013581.1
    • Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking; PGA3 has a paralog, AIM33, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      20761..21699 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182488.1 → NP_013581.1  TPA: cytochrome-b5 reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013581.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0G0, Q12746
      UniProtKB/TrEMBL
      A6ZLU0, B3LLD5, B5VP04, C7GVA6, C8ZE77, N1P680
      Conserved Domains (1) summary
      cd06183
      Location:75 → 312
      cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12746.1

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