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    Ptgr1 prostaglandin reductase 1 [ Mus musculus (house mouse) ]

    Gene ID: 67103, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ptgr1provided by MGI
    Official Full Name
    prostaglandin reductase 1provided by MGI
    Primary source
    MGI:MGI:1914353
    See related
    Ensembl:ENSMUSG00000028378 AllianceGenome:MGI:1914353
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DIG-1; Zadh3; Ltb4dh; 2510002C21Rik
    Summary
    Predicted to enable 13-lipoxin reductase activity; leukotriene B4 12-hydroxy dehydrogenase activity; and oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor. Predicted to be involved in several processes, including fatty acid metabolic process; negative regulation of positive chemotaxis; and negative regulation of reactive oxygen species biosynthetic process. Predicted to be located in cytosol and nucleus. Is expressed in genitourinary system. Orthologous to human PTGR1 (prostaglandin reductase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in bladder adult (RPKM 46.6), stomach adult (RPKM 29.1) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ptgr1 in Genome Data Viewer
    Location:
    4 B3; 4 32.36 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (58965590..58987131, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (58965590..58987131, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Ecm29 proteasome adaptor and scaffold Neighboring gene STARR-positive B cell enhancer ABC_E6181 Neighboring gene zinc finger with KRAB and SCAN domains 16 Neighboring gene STARR-positive B cell enhancer ABC_E9587 Neighboring gene DnaJ heat shock protein family (Hsp40) member C25 Neighboring gene guanine nucleotide binding protein (G protein), gamma 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prostaglandin reductase-3 negatively modulates adipogenesis through regulation of PPARγ activity. Yu YH, et al. J Lipid Res, 2013 Sep. PMID 23821743, Free PMC Article
    2. Six1 homeoprotein drives myofiber type IIA specialization in soleus muscle. Sakakibara I, et al. Skelet Muscle, 2016. PMID 27597886, Free PMC Article
    3. Prosaposin facilitates sortilin-independent lysosomal trafficking of progranulin. Zhou X, et al. J Cell Biol, 2015 Sep 14. PMID 26370502, Free PMC Article
    4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 13-lipoxin reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 2-alkenal reductase (NADPH) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables 2-alkenal reductase (NADPH) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables leukotriene B4 12-hydroxy dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in alkene metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukotriene B4 metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in leukotriene B4 metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipoxin A4 metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of positive chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prostaglandin metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in prostaglandin metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prostaglandin metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    prostaglandin reductase 1
    Names
    15-oxoprostaglandin 13-reductase
    D3T-inducible gene 1 protein
    NAD(P)H-dependent alkenal/one oxidoreductase
    NADP-dependent leukotriene B4 12-hydroxydehydrogenase
    PRG-1
    dithiolethione-inducible gene 1 protein
    leukotriene B4 12-hydroxydehydrogenase
    NP_080244.1
    XP_011248390.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025968.3 → NP_080244.1  prostaglandin reductase 1

      See identical proteins and their annotated locations for NP_080244.1

      Status: PROVISIONAL

      Source sequence(s)
      AK035425
      Consensus CDS
      CCDS18215.1
      UniProtKB/Swiss-Prot
      Q3TKT6, Q91YR9, Q9CPS1
      UniProtKB/TrEMBL
      Q4FJY5
      Related
      ENSMUSP00000030069.7, ENSMUST00000030069.7
      Conserved Domains (2) summary
      TIGR02825
      Location:4 → 328
      B4_12hDH; leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase
      cd08294
      Location:2 → 329
      leukotriene_B4_DH_like; 13-PGR is a bifunctional enzyme with delta-13 15-prostaglandin reductase and leukotriene B4 12 hydroxydehydrogenase activity

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      58965590..58987131 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250088.1 → XP_011248390.1  prostaglandin reductase 1 isoform X1

      Conserved Domains (1) summary
      TIGR02825
      Location:4 → 263
      B4_12hDH; leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91YR9.2 GenPept UniProtKB/Swiss-Prot:Q91YR9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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