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    Chsy3 chondroitin sulfate synthase 3 [ Mus musculus (house mouse) ]

    Gene ID: 78923, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Chsy3provided by MGI
    Official Full Name
    chondroitin sulfate synthase 3provided by MGI
    Primary source
    MGI:MGI:1926173
    See related
    Ensembl:ENSMUSG00000058152 AllianceGenome:MGI:1926173
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4833446K15Rik
    Summary
    Enables N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Involved in chondroitin sulfate biosynthetic process. Is active in Golgi apparatus. Is expressed in articular cartilage; cartilage; cerebral cortex; and humerus. Orthologous to human CHSY3 (chondroitin sulfate synthase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 3.3), limb E14.5 (RPKM 3.1) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Chsy3 in Genome Data Viewer
    Location:
    18 D3; 18 33.93 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (59308412..59544408)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (59175340..59411336)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 19 Neighboring gene STARR-seq mESC enhancer starr_44706 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene membrane integral NOTCH2 associated receptor 2 Neighboring gene predicted gene, 54033 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene Neighboring gene predicted gene, 52338 Neighboring gene microRNA 6355

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor. Izumikawa T, et al. Biochem J, 2007 May 1. PMID 17253960, Free PMC Article
    2. Biosynthesis of chondroitin sulphate by a Golgi-apparatus-enriched preparation from cultures of mouse mastocytoma cells. Silbert JE, et al. Biochem J, 1980 Aug 15. PMID 6781479, Free PMC Article
    3. Chondroitin sulfate N-acetylgalactosaminyltransferase-1 plays a critical role in chondroitin sulfate synthesis in cartilage. Sakai K, et al. J Biol Chem, 2007 Feb 9. PMID 17145758
    4. Sensory Nerve Maintains Intervertebral Disc Extracellular Matrix Homeostasis Via CGRP/CHSY1 Axis. Hu B, et al. Adv Sci (Weinh), 2022 Oct. PMID 36047655, Free PMC Article
    5. Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2. Shimbo M, et al. PLoS One, 2017. PMID 29287114, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chondroitin sulfate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chondroitin sulfate biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    chondroitin sulfate synthase 3
    Names
    N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3
    N-acetylgalactosaminyltransferase 3
    carbohydrate synthase 2
    chSy-2
    chondroitin glucuronyltransferase 3
    chondroitin synthase 2
    glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase II
    NP_001074797.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081328.1 → NP_001074797.1  chondroitin sulfate synthase 3

      See identical proteins and their annotated locations for NP_001074797.1

      Status: PROVISIONAL

      Source sequence(s)
      AC102257, AC127301
      Consensus CDS
      CCDS37829.1
      UniProtKB/Swiss-Prot
      B2RXU7, Q5DTK1
      Related
      ENSMUSP00000079546.5, ENSMUST00000080721.6
      Conserved Domains (3) summary
      pfam05679
      Location:330 → 866
      CHGN; Chondroitin N-acetylgalactosaminyltransferase
      pfam16214
      Location:35 → 165
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      cl21608
      Location:170 → 400
      Galactosyl_T; Galactosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      59308412..59544408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5DTK1.3 GenPept UniProtKB/Swiss-Prot:Q5DTK1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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