PPFIA1 PTPRF interacting protein alpha 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PPFIA1provided by HGNC
Official Full Name: PTPRF interacting protein alpha 1provided by HGNC
Primary source: HGNC:HGNC:9245
See related: Ensembl:ENSG00000131626 MIM:611054; AllianceGenome:HGNC:9245
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LIP1; LIP.1; LIPRIN
Summary: The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. This protein binds to the intracellular membrane-distal phosphatase domain of tyrosine phosphatase LAR, and appears to localize LAR to cell focal adhesions. This interaction may regulate the disassembly of focal adhesion and thus help orchestrate cell-matrix interactions. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in testis (RPKM 18.0), thyroid (RPKM 12.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q13.3

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (70270690..70384396)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (70285642..70404818)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (70116796..70230502)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Liprin-alpha1 contributes to oncogenic MAPK signaling by counteracting ERK activity.
Title: Liprin-α1 contributes to oncogenic MAPK signaling by counteracting ERK activity.
High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor metastasis and poor prognosis.
Title: High expression of PPFIA1 in human esophageal squamous cell carcinoma correlates with tumor metastasis and poor prognosis.
Oligomerized liprin-alpha promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins.
Title: Oligomerized liprin-α promotes phase separation of ELKS for compartmentalization of presynaptic active zone proteins.
Quantifying Polarized Extracellular Matrix Secretion in Cultured Endothelial Cells.
Title: Quantifying Polarized Extracellular Matrix Secretion in Cultured Endothelial Cells.
We found that PPFIA1 and ALG3 were distinctively overexpressed at the mRNA level in HNSCC tissues compared with normal tissues, they had a significant co-occurrence relationship. Patients without both PPFIA1 and ALG3 mRNA expression alterations had better overall survival and disease/progression-free survival compared with patients with both PPFIA1 and ALG3 alterations.
Title: Combined expression and prognostic significance of PPFIA1 and ALG3 in head and neck squamous cell carcinoma.
liprin-alpha1 as a novel regulator of CD82
Title: Liprin-α1 modulates cancer cell signaling by transmembrane protein CD82 in adhesive membrane domains linked to cytoskeleton.
The results indicate that liprin-alpha1, LL5 and ERC1 define a novel dynamic membrane-less compartment that regulates matrix degradation by affecting invadosome motility.
Title: Identification of a membrane-less compartment regulating invadosome function and motility.
This study shows that PPFIA1 is required for FN polymerization-dependent vascular morphogenesis, both in vitro and in the developing zebrafish embryo.
Title: PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis.
Based on these findings, we infer that high PPFIA1 expression might be an independent prognostic indicator of increased metastatic relapse risk in patients with estrogen receptor+/N- breast cancer, but not in estrogen receptor+/N+ or estrogen receptor- patients.
Title: PPFIA1 is upregulated in liver metastasis of breast cancer and is a potential poor prognostic indicator of metastatic relapse.
These results indicate that liprin-alpha1 localizes to different adhesion and cytoskeletal structures to regulate vimentin intermediate filament network, thereby altering the invasion and growth properties of the cancer cells.
Title: Liprin-α1 is a regulator of vimentin intermediate filament network in the cancer cell adhesion machinery.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	HIV-1 Gag interacts with PFFIA1 as demonstrated by proximity dependent biotinylation proteomics	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S1223 (e-PCR)
- UniSTS:60431

STS-N35019 (e-PCR)
- UniSTS:52765

SHGC-35519 (e-PCR)
- UniSTS:46113

SGC36985 (e-PCR)
- UniSTS:11822

SHGC-147791 (e-PCR)
- UniSTS:172878

STS-H97922 (e-PCR)
- UniSTS:34991

SHGC-36533 (e-PCR)
- UniSTS:21219

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-matrix adhesion	TAS Traceable Author Statement more info	PubMed
involved_in cortical microtubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of stress fiber assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in synapse organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	TAS Traceable Author Statement more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in cytosol	TAS Traceable Author Statement more info
located_in focal adhesion	IDA Inferred from Direct Assay more info
is_active_in presynaptic active zone	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic active zone	TAS Traceable Author Statement more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
located_in spine apparatus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: liprin-alpha-1

Names: LAR-interacting protein 1; LIP-1; Liprin-alpha1; protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1; protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001378006.1 → NP_001364935.1 liprin-alpha-1 isoform c

Status: VALIDATED

Source sequence(s)

AP000487, AP002336, KC877433

UniProtKB/TrEMBL

A0A2R8Y7R9

Conserved Domains (5) summary

cd09562
Location:910 → 980

SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1

cd09565
Location:1027 → 1092

SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2

cd09568
Location:1112 → 1183

SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3

COG1196
Location:246 → 546

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:45 → 687

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
NM_003626.5 → NP_003617.1 liprin-alpha-1 isoform b

See identical proteins and their annotated locations for NP_003617.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) represents the longest transcript and it encodes the longer protein (isoform b).

Source sequence(s)

AP000487, AP002336, KC877433

Consensus CDS

CCDS31627.1

UniProtKB/Swiss-Prot

A6NLE3, Q13135, Q13136, Q14567, Q8N4I2

UniProtKB/TrEMBL

A0A2R8Y7R9

Related

ENSP00000253925.7, ENST00000253925.12

Conserved Domains (6) summary

cd09562
Location:875 → 945

SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1

cd09565
Location:962 → 1027

SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2

cd09568
Location:1047 → 1118

SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3

smart00454
Location:1048 → 1118

SAM; Sterile alpha motif

pfam12795
Location:321 → 517

MscS_porin; Mechanosensitive ion channel porin domain

cl12013
Location:324 → 445

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
NM_177423.3 → NP_803172.1 liprin-alpha-1 isoform a

See identical proteins and their annotated locations for NP_803172.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) differs in the 3' end, which includes a part of the coding region and 3' UTR, as compared to variant 2. The resulting protein (isoform a) has a distinct and shorter C-terminus, as compared to isoform b.

Source sequence(s)

AP000487, AP002336, KC877433

Consensus CDS

CCDS31628.1

UniProtKB/TrEMBL

A0A2R8Y7R9

Related

ENSP00000374198.3, ENST00000389547.7

Conserved Domains (6) summary

cd09562
Location:875 → 945

SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1

cd09565
Location:962 → 1027

SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2

cd09568
Location:1047 → 1118

SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3

smart00454
Location:1048 → 1118

SAM; Sterile alpha motif

pfam12795
Location:321 → 517

MscS_porin; Mechanosensitive ion channel porin domain

cl12013
Location:324 → 445

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

NR_045286.3 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses a different splice site in an internal exon and contains an alternate exon, compared to variant 2. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 2, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AP000487, AP002336, KC877433

Related

ENST00000532504.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

70270690..70384396

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006718716.4 → XP_006718779.1 liprin-alpha-1 isoform X1

See identical proteins and their annotated locations for XP_006718779.1

UniProtKB/TrEMBL

A0A2R8Y7R9

Conserved Domains (7) summary

cd09562
Location:949 → 1019

SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1

cd09565
Location:1066 → 1131

SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2

cd09568
Location:1151 → 1222

SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3

smart00454
Location:1152 → 1222

SAM; Sterile alpha motif

pfam00836
Location:416 → 524

Stathmin; Stathmin family

pfam12795
Location:321 → 542

MscS_porin; Mechanosensitive ion channel porin domain

cl12013
Location:324 → 470

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_011545309.3 → XP_011543611.1 liprin-alpha-1 isoform X4

UniProtKB/TrEMBL

A0A2R8Y7R9

Conserved Domains (6) summary

cd09562
Location:949 → 1019

SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1

cd09565
Location:1066 → 1131

SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2

cd09568
Location:1151 → 1222

SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3

smart00454
Location:1152 → 1222

SAM; Sterile alpha motif

pfam00836
Location:416 → 524

Stathmin; Stathmin family

pfam12795
Location:321 → 542

MscS_porin; Mechanosensitive ion channel porin domain
XM_011545307.4 → XP_011543609.1 liprin-alpha-1 isoform X2

UniProtKB/TrEMBL

A0A2R8Y7R9

Conserved Domains (7) summary

cd09562
Location:949 → 1019

SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1

cd09565
Location:1057 → 1122

SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2

cd09568
Location:1142 → 1213

SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3

smart00454
Location:1143 → 1213

SAM; Sterile alpha motif

pfam00836
Location:416 → 524

Stathmin; Stathmin family

pfam12795
Location:321 → 542

MscS_porin; Mechanosensitive ion channel porin domain

cl12013
Location:324 → 470

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_011545311.4 → XP_011543613.1 liprin-alpha-1 isoform X7

UniProtKB/TrEMBL

A0A2R8Y7R9

Conserved Domains (7) summary

cd09562
Location:949 → 1019

SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1

cd09565
Location:1037 → 1102

SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2

cd09568
Location:1122 → 1193

SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3

smart00454
Location:1123 → 1193

SAM; Sterile alpha motif

pfam00836
Location:416 → 524

Stathmin; Stathmin family

pfam12795
Location:321 → 542

MscS_porin; Mechanosensitive ion channel porin domain

cl12013
Location:324 → 470

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_011545312.3 → XP_011543614.1 liprin-alpha-1 isoform X8

UniProtKB/TrEMBL

A0A2R8Y7R9

Conserved Domains (7) summary

cd09562
Location:949 → 1019

SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1

cd09565
Location:1036 → 1101

SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2

cd09568
Location:1121 → 1192

SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3

smart00454
Location:1122 → 1192

SAM; Sterile alpha motif

pfam00836
Location:416 → 524

Stathmin; Stathmin family

pfam12795
Location:321 → 542

MscS_porin; Mechanosensitive ion channel porin domain

cl12013
Location:324 → 470

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_011545308.4 → XP_011543610.1 liprin-alpha-1 isoform X3

UniProtKB/TrEMBL

A0A2R8Y7R9

Conserved Domains (7) summary

cd09562
Location:939 → 1009

SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1

cd09565
Location:1056 → 1121

SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2

cd09568
Location:1141 → 1212

SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3

smart00454
Location:1142 → 1212

SAM; Sterile alpha motif

pfam00836
Location:416 → 524

Stathmin; Stathmin family

pfam12795
Location:321 → 542

MscS_porin; Mechanosensitive ion channel porin domain

cl12013
Location:324 → 470

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_017018448.2 → XP_016873937.1 liprin-alpha-1 isoform X10

UniProtKB/TrEMBL

A0A2R8Y7R9
XM_011545316.3 → XP_011543618.1 liprin-alpha-1 isoform X16

UniProtKB/TrEMBL

A0A2R8Y7R9

Conserved Domains (5) summary

cd09562
Location:910 → 980

SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1

cd09565
Location:997 → 1062

SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2

cd09568
Location:1082 → 1153

SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3

smart00454
Location:1083 → 1153

SAM; Sterile alpha motif

pfam12795
Location:321 → 542

MscS_porin; Mechanosensitive ion channel porin domain
XM_011545314.4 → XP_011543616.1 liprin-alpha-1 isoform X11

UniProtKB/TrEMBL

A0A2R8Y7R9

Conserved Domains (6) summary

cd09562
Location:900 → 970

SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1

cd09565
Location:1017 → 1082

SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2

cd09568
Location:1102 → 1173

SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3

smart00454
Location:1103 → 1173

SAM; Sterile alpha motif

pfam00836
Location:416 → 524

Stathmin; Stathmin family

pfam12795
Location:321 → 542

MscS_porin; Mechanosensitive ion channel porin domain
XM_047427770.1 → XP_047283726.1 liprin-alpha-1 isoform X18

UniProtKB/TrEMBL

A0A2R8Y7R9
XM_047427772.1 → XP_047283728.1 liprin-alpha-1 isoform X21

UniProtKB/TrEMBL

A0A2R8Y7R9
XM_011545317.3 → XP_011543619.1 liprin-alpha-1 isoform X19

UniProtKB/TrEMBL

A0A2R8Y7R9

Conserved Domains (5) summary

cd09562
Location:900 → 970

SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1

cd09565
Location:987 → 1052

SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2

cd09568
Location:1072 → 1143

SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3

smart00454
Location:1073 → 1143

SAM; Sterile alpha motif

pfam12795
Location:321 → 542

MscS_porin; Mechanosensitive ion channel porin domain
XM_047427773.1 → XP_047283729.1 liprin-alpha-1 isoform X22

UniProtKB/TrEMBL

A0A2R8Y7R9
XM_011545310.4 → XP_011543612.1 liprin-alpha-1 isoform X6

UniProtKB/TrEMBL

A0A2R8Y7R9

Conserved Domains (6) summary

cd09562
Location:924 → 994

SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1

cd09565
Location:1041 → 1106

SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2

cd09568
Location:1126 → 1197

SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3

smart00454
Location:1127 → 1197

SAM; Sterile alpha motif

pfam12795
Location:321 → 517

MscS_porin; Mechanosensitive ion channel porin domain

cl12013
Location:324 → 445

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_047427766.1 → XP_047283722.1 liprin-alpha-1 isoform X12

UniProtKB/TrEMBL

A0A2R8Y7R9
XM_047427765.1 → XP_047283721.1 liprin-alpha-1 isoform X9

UniProtKB/TrEMBL

A0A2R8Y7R9
XM_047427767.1 → XP_047283723.1 liprin-alpha-1 isoform X14

UniProtKB/TrEMBL

A0A2R8Y7R9
XM_047427768.1 → XP_047283724.1 liprin-alpha-1 isoform X15

UniProtKB/TrEMBL

A0A2R8Y7R9
XM_011545315.3 → XP_011543617.1 liprin-alpha-1 isoform X13

UniProtKB/TrEMBL

A0A2R8Y7R9, A0AAG2UWZ2

Related

ENSP00000496327.1, ENST00000644155.1

Conserved Domains (6) summary

cd09562
Location:885 → 955

SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1

cd09565
Location:1002 → 1067

SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2

cd09568
Location:1087 → 1158

SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3

smart00454
Location:1088 → 1158

SAM; Sterile alpha motif

pfam12795
Location:321 → 517

MscS_porin; Mechanosensitive ion channel porin domain

cl12013
Location:324 → 445

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_011545319.2 → XP_011543621.1 liprin-alpha-1 isoform X27

UniProtKB/TrEMBL

A0A2R8Y7R9

Conserved Domains (6) summary

cd09562
Location:885 → 955

SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1

cd09565
Location:993 → 1058

SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2

cd09568
Location:1078 → 1149

SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3

smart00454
Location:1079 → 1149

SAM; Sterile alpha motif

pfam12795
Location:321 → 517

MscS_porin; Mechanosensitive ion channel porin domain

cl12013
Location:324 → 445

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_017018449.2 → XP_016873938.1 liprin-alpha-1 isoform X23

UniProtKB/TrEMBL

A0A2R8Y7R9

Conserved Domains (5) summary

cd09562
Location:885 → 955

SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1

cd09565
Location:972 → 1037

SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2

cd09568
Location:1057 → 1128

SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3

COG1196
Location:45 → 441

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

TIGR02168
Location:270 → 517

SMC_prok_B; chromosome segregation protein SMC, common bacterial type
XM_047427769.1 → XP_047283725.1 liprin-alpha-1 isoform X17

UniProtKB/TrEMBL

A0A2R8Y7R9
XM_047427771.1 → XP_047283727.1 liprin-alpha-1 isoform X20

UniProtKB/TrEMBL

A0A2R8Y7R9
XM_047427774.1 → XP_047283730.1 liprin-alpha-1 isoform X24

UniProtKB/TrEMBL

A0A2R8Y7R9
XM_047427775.1 → XP_047283731.1 liprin-alpha-1 isoform X25

UniProtKB/TrEMBL

A0A2R8Y7R9
XM_047427763.1 → XP_047283719.1 liprin-alpha-1 isoform X5

UniProtKB/TrEMBL

A0A2R8Y7R9
XM_047427764.1 → XP_047283720.1 liprin-alpha-1 isoform X6

UniProtKB/TrEMBL

A0A2R8Y7R9
XM_011545306.4 → XP_011543608.1 liprin-alpha-1 isoform X1

See identical proteins and their annotated locations for XP_011543608.1

UniProtKB/TrEMBL

A0A2R8Y7R9

Conserved Domains (7) summary

cd09562
Location:949 → 1019

SAM_liprin-alpha1,2,3,4_repeat1; SAM domain of liprin-alpha1,2,3,4 proteins repeat 1

cd09565
Location:1066 → 1131

SAM_liprin-alpha1,2,3,4_repeat2; SAM domain of liprin-alpha1,2,3,4 proteins repeat 2

cd09568
Location:1151 → 1222

SAM_liprin-alpha1,2,3,4_repeat3; SAM domain of liprin-alpha1,2,3,4 proteins repeat 3

smart00454
Location:1152 → 1222

SAM; Sterile alpha motif

pfam00836
Location:416 → 524

Stathmin; Stathmin family

pfam12795
Location:321 → 542

MscS_porin; Mechanosensitive ion channel porin domain

cl12013
Location:324 → 470

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_047427776.1 → XP_047283732.1 liprin-alpha-1 isoform X26

UniProtKB/TrEMBL

Q59FZ5