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    Tmem245 transmembrane protein 245 [ Mus musculus (house mouse) ]

    Gene ID: 242474, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem245provided by MGI
    Official Full Name
    transmembrane protein 245provided by MGI
    Primary source
    MGI:MGI:2445107
    See related
    Ensembl:ENSMUSG00000055296 AllianceGenome:MGI:2445107
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A630051L19Rik; D730040F13Rik
    Summary
    Predicted to be located in membrane. Is expressed in blood vessel; dorsal root ganglion; trigeminal ganglion; vagus ganglion; and vestibulo-cochlear ganglion. Orthologous to human TMEM245 (transmembrane protein 245). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 6.9), lung adult (RPKM 6.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem245 in Genome Data Viewer
    Location:
    4 B3; 4 31.66 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (56866923..56947456, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (56876003..56947455, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene elongator complex protein 1 Neighboring gene actin binding transcription modulator Neighboring gene catenin alpha like 1 Neighboring gene STARR-seq mESC enhancer starr_10312 Neighboring gene STARR-positive B cell enhancer ABC_E9083 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:56928950-56929103 Neighboring gene predicted gene, 25053 Neighboring gene STARR-seq mESC enhancer starr_10314 Neighboring gene microRNA 32 Neighboring gene predicted gene, 22300 Neighboring gene STARR-seq mESC enhancer starr_10316 Neighboring gene ferric-chelate reductase 1 like Neighboring gene erythrocyte membrane protein band 4.1 like 4b Neighboring gene predicted gene, 34738

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of transcripts with enriched expression in the developing and adult pancreas. Hoffman BG, et al. Genome Biol, 2008. PMID 18554416, Free PMC Article
    2. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 245
    Names
    likely ortholog of H. sapiens chromosome 9 open reading frame 5 (C9orf5)
    transmembrane 245

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001369260.1 → NP_001356189.1  transmembrane protein 245 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL929577, BX470220
      Consensus CDS
      CCDS89746.1
      UniProtKB/Swiss-Prot
      B1AZA5
      Related
      ENSMUSP00000067421.7, ENSMUST00000068792.13
      Conserved Domains (1) summary
      cl00465
      Location:591 → 837
      AI-2E_transport; AI-2E family transporter

    2. NM_001369261.1 → NP_001356190.1  transmembrane protein 245 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL929577, BX470220
      Conserved Domains (1) summary
      cl00465
      Location:583 → 829
      AI-2E_transport; AI-2E family transporter

    3. NM_175518.5 → NP_780727.3  transmembrane protein 245 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI509120, AL929577, BB810057, BX470220, CF538713, CJ067096
      Consensus CDS
      CCDS38767.1
      UniProtKB/TrEMBL
      D3YWD3
      Related
      ENSMUSP00000103234.4, ENSMUST00000107609.4
      Conserved Domains (1) summary
      cl00465
      Location:651 → 841
      UPF0118; Domain of unknown function DUF20

    RNA

    1. NR_161227.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL929577, BX470220

    2. NR_161228.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL929577, BX470220

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      56866923..56947456 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250037.4 → XP_011248339.1  transmembrane protein 245 isoform X1

      Conserved Domains (1) summary
      cl00465
      Location:659 → 849
      AI-2E_transport; AI-2E family transporter

    2. XM_036164125.1 → XP_036020018.1  transmembrane protein 245 isoform X4

      UniProtKB/TrEMBL
      B1AZA8
      Related
      ENSMUSP00000117449.2, ENSMUST00000132816.8
      Conserved Domains (1) summary
      cl00465
      Location:214 → 404
      AI-2E_transport; AI-2E family transporter

    3. XM_011250038.4 → XP_011248340.1  transmembrane protein 245 isoform X2

    4. XM_011250039.4 → XP_011248341.1  transmembrane protein 245 isoform X3

    RNA

    1. XR_004941894.1 RNA Sequence

    2. XR_004941893.1 RNA Sequence

    3. XR_001784143.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1AZA5.1 GenPept UniProtKB/Swiss-Prot:B1AZA5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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