TEAD1 TEA domain transcription factor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TEAD1provided by HGNC
Official Full Name: TEA domain transcription factor 1provided by HGNC
Primary source: HGNC:HGNC:11714
See related: Ensembl:ENSG00000187079 MIM:189967; AllianceGenome:HGNC:11714
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AA; REF1; TCF13; TEF-1; NTEF-1; TCF-13; TEAD-1
Summary: This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]
Expression: Ubiquitous expression in fat (RPKM 17.6), esophagus (RPKM 16.7) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p15.3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (12674421..12944737)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (12766927..13037265)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (12695968..12966284)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MKLN1-AS promotes pancreatic cancer progression as a crucial downstream mediator of HIF-1alpha through miR-185-5p/TEAD1 pathway.
Title: MKLN1-AS promotes pancreatic cancer progression as a crucial downstream mediator of HIF-1α through miR-185-5p/TEAD1 pathway.
TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis.
Title: TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis.
SUMOylation of TEAD1 Modulates the Mechanism of Pathological Cardiac Hypertrophy.
Title: SUMOylation of TEAD1 Modulates the Mechanism of Pathological Cardiac Hypertrophy.
Mechanosignaling YAP/TAZ-TEAD Axis Regulates the Immunomodulatory Properties of Mesenchymal Stem Cells.
Title: Mechanosignaling YAP/TAZ-TEAD Axis Regulates the Immunomodulatory Properties of Mesenchymal Stem Cells.
Long non-coding HOXA-AS3 contributes to osteosarcoma progression through the miR-1286/TEAD1 axis.
Title: Long non-coding HOXA-AS3 contributes to osteosarcoma progression through the miR-1286/TEAD1 axis.
Nuclear proinflammatory cytokine S100A9 enhances expression of human papillomavirus oncogenes via transcription factor TEAD1.
Title: Nuclear proinflammatory cytokine S100A9 enhances expression of human papillomavirus oncogenes via transcription factor TEAD1.
Distinct response of adipocyte progenitors to glucocorticoids determines visceral obesity via the TEAD1-miR-27b-PRDM16 axis.
Title: Distinct response of adipocyte progenitors to glucocorticoids determines visceral obesity via the TEAD1-miR-27b-PRDM16 axis.
TEAD1 trapping by the Q353R-Lamin A/C causes dilated cardiomyopathy.
Title: TEAD1 trapping by the Q353R-Lamin A/C causes dilated cardiomyopathy.
VGLL4-TEAD1 promotes vascular smooth muscle cell differentiation from human pluripotent stem cells via TET2.
Title: VGLL4-TEAD1 promotes vascular smooth muscle cell differentiation from human pluripotent stem cells via TET2.
TEAD1 regulates cell proliferation through a pocket-independent transcription repression mechanism.
Title: TEAD1 regulates cell proliferation through a pocket-independent transcription repression mechanism.

Submit: New GeneRIF Correction See all GeneRIFs (71)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Helicoid peripapillary chorioretinal degeneration MedGen: C1862382 OMIM: 108985 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
Hundreds of variants clustered in genomic loci and biological pathways affect human height. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S1315 (e-PCR)
- UniSTS:1540

D11S1315 (e-PCR)
- UniSTS:9481

G35333 (e-PCR)
- UniSTS:34060

D11S1323 (e-PCR), detects polymorphism
- UniSTS:67612

D11S1154 (e-PCR)
- UniSTS:59688

D11S1334 (e-PCR), detects polymorphism
- UniSTS:71473

D11S1222 (e-PCR)
- UniSTS:47946

D11S4116 (e-PCR), detects polymorphism
- UniSTS:3422

D11S2690 (e-PCR)
- UniSTS:151914

SHGC-82961 (e-PCR)
- UniSTS:96118

D11S902 (e-PCR), detects polymorphism
- UniSTS:31863

RH48654 (e-PCR)
- UniSTS:65938

SHGC-107541 (e-PCR)
- UniSTS:170408

D11S1315 (e-PCR)
- UniSTS:37547

RH68897 (e-PCR)
- UniSTS:45239

RH36447 (e-PCR)
- UniSTS:67256

RH75549 (e-PCR)
- UniSTS:89806

D11S4934 (e-PCR)
- UniSTS:474577

D11S4935 (e-PCR)
- UniSTS:474578

SHGC-70156 (e-PCR)
- UniSTS:182489

TEAD1_2044 (e-PCR)
- UniSTS:281051

RH66129 (e-PCR)
- UniSTS:49908

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in embryonic organ development	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in hippo signaling	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of miRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of TEAD-YAP complex	IDA Inferred from Direct Assay more info	PubMed
part_of TEAD-YAP complex	IPI Inferred from Physical Interaction more info	PubMed
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcriptional enhancer factor TEF-1

Names: TEA domain family member 1 (SV40 transcriptional enhancer factor); protein GT-IIC; transcription factor 13; transcriptional enhancer factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.