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    Sod3 Superoxide dismutase 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36232, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sod3provided by FlyBase
    Official Full Name
    Superoxide dismutase 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0033631
    Locus tag
    Dmel_CG9027
    See related
    AllianceGenome:FB:FBgn0033631
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG13200; CG9027; CT25938; Dmel/CG9027; Dmel\CG9027; dSod3; dSOD3; sod-3; SOD3
    Summary
    Enables superoxide dismutase activity. Involved in UV protection and removal of superoxide radicals. Located in extracellular space. Is expressed in anterior midgut primordium; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Orthologous to human SOD1 (superoxide dismutase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sod3 in Genome Data Viewer
    Location:
    47F7-47F8; 2-64 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11380347..11384114, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7267852..7271619, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tetraspanin 47F Neighboring gene sprite Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Threonine-TGT 2-1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular phylogenetic evidence for an extracellular Cu Zn superoxide dismutase gene in insects. Parker JD, et al. Insect Mol Biol, 2004 Dec. PMID 15606807
    2. Orthologs of NOX5 and EC-SOD/SOD3: dNox and dSod3 Impact Egg Hardening Process and Egg Laying in Reproductive Function of Drosophila melanogaster. Steinmetz EL, et al. Int J Mol Sci, 2024 Jun 2. PMID 38892326, Free PMC Article
    3. Assessing Curcumin Uptake and Clearance and Their Influence on Superoxide Dismutase Activity in Drosophila melanogaster. Hoffman TR, et al. BioTech (Basel), 2023 Sep 8. PMID 37754202, Free PMC Article
    4. Bifidobacterium adolescentis regulates catalase activity and host metabolism and improves healthspan and lifespan in multiple species. Chen S, et al. Nat Aging, 2021 Nov. PMID 37118342
    5. Cloning and expression analysis of Drosophila extracellular Cu Zn superoxide dismutase. Blackney MJ, et al. Biosci Rep, 2014 Dec 23. PMID 25339624, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show higher levels of expression of Sod3 (extracellular Cu Zn superoxide dismutase) in females.
      Title: Cloning and expression analysis of Drosophila extracellular Cu Zn superoxide dismutase.
    2. found that dSod3 not only retains SOD activity but also properties of secreted proteins, as do other SOD3s
      Title: Identification of Drosophila SOD3 and its protective role against phototoxic damage to cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables superoxide dismutase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables superoxide dismutase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables superoxide dismutase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in UV protection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in removal of superoxide radicals IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in removal of superoxide radicals IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in superoxide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    superoxide dismutase 3
    Names
    CG9027-PA
    CG9027-PB
    CG9027-PD
    CG9027-PE
    CG9027-PF
    Sod3-PA
    Sod3-PB
    Sod3-PD
    Sod3-PE
    Sod3-PF
    NP_001033939.2
    NP_001036536.1
    NP_001303344.1
    NP_610682.2
    NP_725046.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11380347..11384114 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001043071.2 → NP_001036536.1  superoxide dismutase 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036536.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JR71
      Conserved Domains (1) summary
      pfam00080
      Location:42 → 178
      Sod_Cu; Copper/zinc superoxide dismutase (SODC)

    2. NM_001038850.2 → NP_001033939.2  superoxide dismutase 3, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001033939.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z8K9
      Conserved Domains (1) summary
      pfam00080
      Location:43 → 178
      Sod_Cu; Copper/zinc superoxide dismutase (SODC)

    3. NM_001316415.1 → NP_001303344.1  superoxide dismutase 3, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D8FT33, Q0E9C3, Q5U195, Q7JR71, Q95T42
      Conserved Domains (1) summary
      pfam00080
      Location:38 → 178
      Sod_Cu; Copper/zinc superoxide dismutase (SODC)

    4. NM_165829.3 → NP_725046.2  superoxide dismutase 3, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725046.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D8FT33, Q0E9C3, Q5U195, Q7JR71, Q95T42
      Related
      FBpp0088877
      Conserved Domains (1) summary
      pfam00080
      Location:38 → 178
      Sod_Cu; Copper/zinc superoxide dismutase (SODC)

    5. NM_136838.3 → NP_610682.2  superoxide dismutase 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610682.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D8FT33, Q0E9C3, Q5U195, Q7JR71, Q95T42
      Related
      FBpp0088878
      Conserved Domains (1) summary
      pfam00080
      Location:38 → 178
      Sod_Cu; Copper/zinc superoxide dismutase (SODC)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z8K9 A1Z8K9
    Q7JR71.1 Q7JR71

    Gene LinkOut

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