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    CG12493 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38575, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG12493provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035571
    Locus tag
    Dmel_CG12493
    See related
    AllianceGenome:FB:FBgn0035571
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg12493; Dmel\CG12493
    Summary
    Enables siRNA binding activity. Located in nucleus. Is expressed in adult head; clypeo-labral primordium; and gonad. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG12493 in Genome Data Viewer
    Location:
    64B16-64B16; 3-12 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4752393..4753738, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4752393..4753738, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor at 64C Neighboring gene long non-coding RNA:CR43882 Neighboring gene long non-coding RNA:CR45984 Neighboring gene long non-coding RNA:CR43881 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of a novel Drosophila melanogaster cis-regulatory module that drives gene expression to the larval tracheal system and adult thoracic musculature. Wester JVWC, et al. Genesis, 2018 Aug. PMID 30096221
    2. Trafficking of siRNA precursors by the dsRBD protein Blanks in Drosophila. Nitschko V, et al. Nucleic Acids Res, 2020 Apr 17. PMID 32025726, Free PMC Article
    3. Blanks, a nuclear siRNA/dsRNA-binding complex component, is required for Drosophila spermiogenesis. Gerbasi VR, et al. Proc Natl Acad Sci U S A, 2011 Feb 22. PMID 21300896, Free PMC Article
    4. Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability. Samuels TJ, et al. Elife, 2020 Jan 14. PMID 31934860, Free PMC Article
    5. Cyclin-dependent kinase 8 module expression profiling reveals requirement of mediator subunits 12 and 13 for transcription of Serpent-dependent innate immunity genes in Drosophila. Kuuluvainen E, et al. J Biol Chem, 2014 Jun 6. PMID 24778181, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables double-stranded RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables siRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG12493-PA
    CG12493-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      4752393..4753738 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274497.1 → NP_001261426.1  uncharacterized protein Dmel_CG12493, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261426.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHF9
      Conserved Domains (1) summary
      smart00358
      Location:226 → 286
      DSRM; Double-stranded RNA binding motif

    2. NM_139670.3 → NP_647927.3  uncharacterized protein Dmel_CG12493, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647927.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8T4B3, Q9VZ88
      Related
      FBpp0073219
      Conserved Domains (1) summary
      smart00358
      Location:229 → 289
      DSRM; Double-stranded RNA binding motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PHF9 M9PHF9
    Q9VZ88 Q9VZ88

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