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    Tis11 Tis11 zinc finger protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32222, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tis11provided by FlyBase
    Official Full Name
    Tis11 zinc finger proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011837
    Locus tag
    Dmel_CG4070
    See related
    AllianceGenome:FB:FBgn0011837
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:Liang-1.28; CG4070; clone 1.28; Dmel\CG4070; dTis11; dTIS11; DTIS11; DTIS11-RC; dTTP; l(1)G0124; tis-11; tis11; TIS11; TIS11cc1; TIScc1; Ts11
    Summary
    Enables mRNA 3'-UTR AU-rich region binding activity. Involved in 3'-UTR-mediated mRNA destabilization; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and regulatory ncRNA-mediated post-transcriptional gene silencing. Located in cytosol. Is expressed in adult brain cell body rind; adult gnathal ganglion; and organism. Orthologous to human ZFP36L1 (ZFP36 ring finger protein like 1) and ZFP36L2 (ZFP36 ring finger protein like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tis11 in Genome Data Viewer
    Location:
    11B9-11B10; 1-39 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (12659415..12682560)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (12553448..12576587)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene tomosyn Neighboring gene mir-970 stem loop Neighboring gene long non-coding RNA:CR33963 Neighboring gene Casein kinase Ialpha Neighboring gene mir-9377 stem loop Neighboring gene Scutellar Macrochaetes Regulatory Gene Neighboring gene Smrter Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43963

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila TIS11 homologue encodes a developmentally controlled gene. Ma Q, et al. Oncogene, 1994 Nov. PMID 7936658
    2. Rapid proteasomal degradation of posttranscriptional regulators of the TIS11/tristetraprolin family is induced by an intrinsically unstructured region independently of ubiquitination. Ngoc LV, et al. Mol Cell Biol, 2014 Dec 1. PMID 25246635, Free PMC Article
    3. dTIS11 Protein-dependent polysomal deadenylation is the key step in AU-rich element-mediated mRNA decay in Drosophila cells. Vindry C, et al. J Biol Chem, 2012 Oct 12. PMID 22932903, Free PMC Article
    4. A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3'UTR-Mediated Protein-Protein Interactions. Ma W, et al. Cell, 2018 Nov 29. PMID 30449617, Free PMC Article
    5. A Drosophila melanogaster homolog of the TIS11 family of immediate early genes that can rescue a cdr1 cdc25 mutant strain of fission yeast. Warbrick E, et al. Gene, 1994 Dec 30. PMID 7828883

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. we observed that dtis11 expression contributes to cell metabolic and proliferative recovery upon reoxygenation. Altogether, our data demonstrate that AMD plays an important role in the control of gene expression upon variation in oxygen concentration and contributes to optimal metabolic adaptation to oxygen variations.
      Title: ARE-mediated decay controls gene expression and cellular metabolism upon oxygen variations.
    2. Data indicate that Tis11 protein can affect post-transcriptional gene expression in adult flies by regulating mRNA decay.
      Title: The Drosophila Tis11 protein and its effects on mRNA expression in flies.
    3. the Drosophila melanogaster dTIS11 protein is short-lived due to its rapid ubiquitin-independent degradation by the proteasome.
      Title: Rapid proteasomal degradation of posttranscriptional regulators of the TIS11/tristetraprolin family is induced by an intrinsically unstructured region independently of ubiquitination.
    4. Nuclear export of TIS11 proteins is mediated by CRM1 through diverging nuclear export signals, while their nuclear import mechanism may rely on a highly conserved signal whose activity is negatively regulated by ZnF2 folding.
      Title: A masked PY-NLS in Drosophila TIS11 and its mammalian homolog tristetraprolin.
    5. overexpression of dTIS11 does not promote the localization of ARE-containing mRNAs in P-bodies but rather decreases the accumulation of CecA1 mRNA in these structures by enhancing the degradation process
      Title: dTIS11 Protein-dependent polysomal deadenylation is the key step in AU-rich element-mediated mRNA decay in Drosophila cells.
    6. study identified a novel mRNA target of DTIS11, eya, and provided evidence that DTIS11 regulates eye development by interacting with and destabilizing eya mRNA, especially during embryogenesis
      Title: Drosophila eyes absent is a novel mRNA target of the tristetraprolin (TTP) protein DTIS11.
    7. The functionality of CecA1 ARE relies on its ability to recruit TIS11 protein, which accelerates CecA1 mRNA deadenylation and decay
      Title: Post-transcriptional Regulation of Genes Encoding Anti-microbial Peptides in Drosophila.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA 3'-UTR AU-rich region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    Tis11 zinc finger protein
    Names
    CG4070-PA
    CG4070-PC
    CG4070-PD
    Tis11 homolog
    Tis11-PA
    Tis11-PC
    Tis11-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      12659415..12682560
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272561.2 → NP_001259490.1  Tis11 zinc finger protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259490.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P47980, Q8IR77, Q9VYK1
      UniProtKB/TrEMBL
      B3DN56
      Conserved Domains (1) summary
      pfam00642
      Location:136 → 161
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

    2. NM_078586.5 → NP_511141.2  Tis11 zinc finger protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511141.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P47980, Q8IR77, Q9VYK1
      UniProtKB/TrEMBL
      B3DN56
      Related
      FBpp0073516
      Conserved Domains (1) summary
      pfam00642
      Location:136 → 161
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

    3. NM_167333.4 → NP_727633.2  Tis11 zinc finger protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727633.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P47980, Q8IR77, Q9VYK1
      UniProtKB/TrEMBL
      B3DN56
      Conserved Domains (1) summary
      pfam00642
      Location:136 → 161
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B3DN56 B3DN56
    P47980.2 P47980

    Gene LinkOut

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