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    Mlf Myelodysplasia/myeloid leukemia factor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36750, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mlfprovided by FlyBase
    Official Full Name
    Myelodysplasia/myeloid leukemia factorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034051
    Locus tag
    Dmel_CG8295
    See related
    AllianceGenome:FB:FBgn0034051
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:SD18148; CG8295; Dmel\CG8295; dmlf; dMLF; mlf; MLF
    Summary
    Enables DNA-binding transcription factor binding activity and protein-folding chaperone binding activity. Involved in several processes, including positive regulation of crystal cell differentiation; protein stabilization; and regulation of cell proliferation involved in compound eye morphogenesis. Located in nucleus; perinuclear region of cytoplasm; and polytene chromosome interband. Is expressed in several structures, including central brain primordium; embryonic/larval garland cell; embryonic/larval hemocyte; embryonic/larval midgut primordium; and ganglia. Orthologous to several human genes including MLF2 (myeloid leukemia factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Mlf in Genome Data Viewer
    Location:
    52D2-52D3; 2-76 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15935893..15940073, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11823398..11827578, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene bedraggled Neighboring gene Death-associated inhibitor of apoptosis 2 Neighboring gene bunker gear Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 4aa1 Neighboring gene Cytochrome c oxidase subunit 6A-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of novel nuclear localization signals of Drosophila myeloid leukemia factor. Sugano W, et al. Cell Struct Funct, 2007. PMID 18159124
    2. Evidence for sequestration of polyglutamine inclusions by Drosophila myeloid leukemia factor. Kim WY, et al. Mol Cell Neurosci, 2005 Aug. PMID 15936212
    3. The myeloid leukemia factor interacts with COP9 signalosome subunit 3 in Drosophila melanogaster. Sugano W, et al. FEBS J, 2008 Feb. PMID 18199288
    4. NPM-hMLF1 fusion protein suppresses defects of a Drosophila FTLD model expressing the human FUS gene. Yamamoto I, et al. Sci Rep, 2018 Jul 26. PMID 30050143, Free PMC Article
    5. Characterization of a Drosophila homologue of the human myelodysplasia/myeloid leukemia factor (MLF). Ohno K, et al. Gene, 2000 Dec 30. PMID 11137299

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our data indicate that the MLF/DnaJ-1-dependent increase in Lz level allows the repression of Notch expression and signaling to prevent aberrant blood cell development. Thus our findings establish a functional link between MLF and the co-chaperone DnaJ-1 to control RUNX transcription factor activity and Notch signaling during blood cell development in vivo.
      Title: Control of RUNX-induced repression of Notch signaling by MLF and its partner DnaJ-1 during Drosophila hematopoiesis.
    2. mlf participates in a positive feedback loop to fine tune the activity of the RUNX transcription factor Lozenge (LZ) during development of the crystal cells.
      Title: Myeloid leukemia factor is a conserved regulator of RUNX transcription factor activity involved in hematopoiesis.
    3. Data revealed that MLF interacts with CSN3 in vivo and that the PCI domain of the dCSN3 protein is sufficient for this to occur, possibly functioning as a structural scaffold for assembly of the COP9 signalosome complex.
      Title: The myeloid leukemia factor interacts with COP9 signalosome subunit 3 in Drosophila melanogaster.
    4. MLF1 has been described as mainly cytoplasmic, but in Drosophila, one of the dMLF isoforms (dMLFA) localized mainly in the nucleus.
      Title: Identification of novel nuclear localization signals of Drosophila myeloid leukemia factor.
    5. Mlf and its mutant were characterized. Mlf can act developmentaly and post-developmentally to suppress neurodegeneration and premature aging in a cerebellar ataxia model.
      Title: Characterization of the Drosophila myeloid leukemia factor.
    6. role in the control of cell growth in eye development
      Title: A genomic switch at the transition from cell proliferation to terminal differentiation in the Drosophila eye.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of crystal cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of crystal cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell proliferation involved in compound eye morphogenesis IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in polytene chromosome interband IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Myelodysplasia/myeloid leukemia factor
    Names
    CG8295-PA
    CG8295-PB
    CG8295-PC
    CG8295-PD
    CG8295-PE
    CG8295-PF
    CG8295-PG
    CG8295-PH
    Mlf-PA
    Mlf-PB
    Mlf-PC
    Mlf-PD
    Mlf-PE
    Mlf-PF
    Mlf-PG
    Mlf-PH
    drosophila myeloid leukemia factor
    myeloid leukemia factor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15935893..15940073 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206125.2 → NP_995847.1  Myelodysplasia/myeloid leukemia factor, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995847.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1ZA61, A1ZA62, Q540Y3, Q8IG90, Q95P43, Q9NKV0, Q9V7G3
      UniProtKB/TrEMBL
      C0PUX0
      Conserved Domains (1) summary
      pfam10248
      Location:37 → 199
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

    2. NM_001169693.1 → NP_001163164.1  Myelodysplasia/myeloid leukemia factor, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163164.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PUX0, E1JH79
      Conserved Domains (1) summary
      pfam10248
      Location:37 → 199
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

    3. NM_166123.4 → NP_725502.1  Myelodysplasia/myeloid leukemia factor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725502.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMK9
      Related
      FBpp0086429
      Conserved Domains (1) summary
      pfam10248
      Location:37 → 199
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

    4. NM_079029.5 → NP_523753.1  Myelodysplasia/myeloid leukemia factor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523753.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DMK9
      Related
      FBpp0086428
      Conserved Domains (1) summary
      pfam10248
      Location:37 → 199
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

    5. NM_001259425.1 → NP_001246354.1  Myelodysplasia/myeloid leukemia factor, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246354.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K807, D3DN03
      Conserved Domains (1) summary
      pfam10248
      Location:16 → 178
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

    6. NM_166122.4 → NP_725501.2  Myelodysplasia/myeloid leukemia factor, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725501.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      D3DN03
      Related
      FBpp0086430
      Conserved Domains (1) summary
      pfam10248
      Location:35 → 197
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

    7. NM_001259424.2 → NP_001246353.1  Myelodysplasia/myeloid leukemia factor, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246353.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7R5, D3DN03
      Conserved Domains (1) summary
      pfam10248
      Location:35 → 197
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein

    8. NM_001259426.2 → NP_001246355.1  Myelodysplasia/myeloid leukemia factor, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246355.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C0PUX0, E1JH79
      Conserved Domains (1) summary
      pfam10248
      Location:37 → 199
      Mlf1IP; Myelodysplasia-myeloid leukemia factor 1-interacting protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K7R5 A0A0B4K7R5
    A0A0B4K807 A0A0B4K807
    E1JH79 E1JH79
    Q9NKV0.2 Q9NKV0

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