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    Mal-A8 Maltase A8 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35830, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mal-A8provided by FlyBase
    Official Full Name
    Maltase A8provided by FlyBase
    Primary source
    FLYBASE:FBgn0033297
    Locus tag
    Dmel_CG8690
    See related
    AllianceGenome:FB:FBgn0033297
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8690; CT6532; Dmel\CG8690; Drome_A8; mal_A8
    Summary
    Predicted to enable alpha-1,4-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult head. Human ortholog(s) of this gene implicated in cystinuria. Orthologous to human SLC3A1 (solute carrier family 3 member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mal-A8 in Genome Data Viewer
    Location:
    44D1-44D1; 2-59 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8471954..8473961)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4359459..4361466)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Maltase A6 Neighboring gene Maltase A7 Neighboring gene mangetout Neighboring gene long non-coding RNA:CR44279 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Association between duplicated maltase genes and the transcriptional regulation for the carbohydrate changes in Drosophila melanogaster. Inomata N, et al. Gene, 2019 Feb 20. PMID 30399425
    2. Differential gene expression by RNA-seq during Alzheimer's disease-like progression in the Drosophila melanogaster model. da Costa Silva JR, et al. Neurosci Res, 2022 Jul. PMID 35219723
    3. Assessment of genome-wide protein function classification for Drosophila melanogaster. Mi H, et al. Genome Res, 2003 Sep. PMID 12952880, Free PMC Article
    4. AMPK signaling linked to the schizophrenia-associated 1q21.1 deletion is required for neuronal and sleep maintenance. Nagy S, et al. PLoS Genet, 2018 Dec. PMID 30566533, Free PMC Article
    5. Transient adult microbiota, gut homeostasis and longevity: novel insights from the Drosophila model. Erkosar B, et al. FEBS Lett, 2014 Nov 17. PMID 24983497

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-1,4-glucosidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    maltase A8
    Names
    CG8690-PA
    Mal-A8-PA
    NP_610384.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8471954..8473961
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136540.3 → NP_610384.1  maltase A8 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610384.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z7F3, H5V882
      Related
      FBpp0087831
      Conserved Domains (3) summary
      cd11328
      Location:30 → 506
      AmyAc_maltase; Alpha amylase catalytic domain found in maltase (also known as alpha glucosidase) and related proteins
      TIGR02403
      Location:33 → 585
      trehalose_treC; alpha,alpha-phosphotrehalase
      cl02706
      Location:487 → 585
      Malt_amylase_C; Maltogenic Amylase, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z7F3 A1Z7F3
    Q8MS80 Q8MS80

    Gene LinkOut

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