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    Tpl94D Transition protein-like 94D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 318658, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tpl94Dprovided by FlyBase
    Official Full Name
    Transition protein-like 94Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051281
    Locus tag
    Dmel_CG31281
    See related
    AllianceGenome:FB:FBgn0051281
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31281; Dmel\CG31281; NEST:bs11b10; NEST:bs30g09; tpl; tpl94D; tpl[94D]; Tpl[94D]
    Summary
    Involved in sperm DNA condensation. Located in nucleus. Is expressed in mid-late elongation-stage spermatid and testis. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tpl94D in Genome Data Viewer
    Location:
    94D5-94D5; 3-77 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22966284..22967842)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18792006..18793564)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene klingon Neighboring gene long non-coding RNA:CR46088 Neighboring gene long non-coding RNA:CR43655 Neighboring gene Growth-blocking peptide 3 Neighboring gene Na[+]/H[+] hydrogen antiporter 2 Neighboring gene Odorant receptor 94a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genomic and expression analysis of transition proteins in Drosophila. Alvi ZA, et al. Spermatogenesis, 2015 Sep-Dec. PMID 27512614, Free PMC Article
    2. Expansion and loss of sperm nuclear basic protein genes in Drosophila correspond with genetic conflicts between sex chromosomes. Chang CH, et al. Elife, 2023 Feb 10. PMID 36763410, Free PMC Article
    3. Histone H4 acetylation is essential to proceed from a histone- to a protamine-based chromatin structure in spermatid nuclei of Drosophila melanogaster. Awe S, et al. Syst Biol Reprod Med, 2010 Feb. PMID 20170286
    4. The Drosophila cell adhesion molecule klingon is required for long-term memory formation and is regulated by Notch. Matsuno M, et al. Proc Natl Acad Sci U S A, 2009 Jan 6. PMID 19104051, Free PMC Article
    5. The poly(A) polymerase GLD2 is required for spermatogenesis in Drosophila melanogaster. Sartain CV, et al. Development, 2011 Apr. PMID 21427144, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in sperm DNA condensation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sperm DNA condensation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transition protein-like 94D
    Names
    CG31281-PA
    CG31281-PB
    Tpl94D-PA
    Tpl94D-PB
    transition protein-like[94D]

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22966284..22967842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170042.2 → NP_732806.1  transition protein-like 94D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732806.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q1RKV4, Q8IMZ6
      Related
      FBpp0083732
      Conserved Domains (1) summary
      pfam06382
      Location:16 → 61
      DUF1074; Protein of unknown function (DUF1074)

    2. NM_001275925.1 → NP_001262854.1  transition protein-like 94D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262854.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHN9
      Conserved Domains (1) summary
      pfam06382
      Location:16 → 77
      DUF1074; Protein of unknown function (DUF1074)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHN9 A0A0B4KHN9
    Q8IMZ6 Q8IMZ6

    Gene LinkOut

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