Trpgamma Transient receptor potential cation channel gamma [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Trpgammaprovided by FlyBase
Official Full Name: Transient receptor potential cation channel gammaprovided by FlyBase
Primary source: FLYBASE:FBgn0032593
Locus tag: Dmel_CG5996
See related: AllianceGenome:FB:FBgn0032593
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG5996; Dmel\CG5996; DmTRPgamma; dTRPg; dTRPgamma; trp-gamma; Trp-gamma; trpgamma; TRPgamma
Summary: Enables mechanosensitive monoatomic ion channel activity and monoatomic cation channel activity. Involved in adult walking behavior; monoatomic cation transport; and neuromuscular process controlling posture. Located in neuronal cell body; proximal dendrite; and rhabdomere. Part of cation channel complex. Is expressed in femoral chordotonal organ and spermatozoon. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in lung cancer. Orthologous to several human genes including TRPC4 (transient receptor potential cation channel subfamily C member 4) and TRPC5 (transient receptor potential cation channel subfamily C member 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 36A9-36A10; 2-52 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (16663454..16676701, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (16663454..16676701, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRPgamma contributes to fine motor control through mechanical activation in proprioceptive organs, thereby promoting Ca(2+) influx, which is required for function.
Title: Coordination and fine motor control depend on Drosophila TRPγ.
Forms a fly cation channel responsible for the regulation of intracellular calcium in a variety of hormonal signaling cascades.
Title: Receptor-induced activation of Drosophila TRP gamma by polyunsaturated fatty acids.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

mobile_element

Loc: c16665715-16665658 mobile_element_type = transposon:INE-1{}3317

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables mechanosensitive monoatomic ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in detection of light stimulus involved in visual perception	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in monoatomic cation transport	IDA Inferred from Direct Assay more info	PubMed
involved_in neuromuscular process controlling posture	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to light stimulus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to light stimulus	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cation channel complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in proximal dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in rhabdomere	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transient receptor potential cation channel gamma

Names: CG5996-PA; CG5996-PB; CG5996-PD; Trpgamma-PA; Trpgamma-PB; Trpgamma-PD; trpgamma

NP_001137830.2

non-AUG (CUG) translation initiation

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

16663454..16676701 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001144358.3 → NP_001137830.2 transient receptor potential cation channel gamma, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001137830.2

Status: REVIEWED

UniProtKB/TrEMBL

B7YZW4

Conserved Domains (5) summary

cd00204
Location:113 → 217

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:77 → 841

trp; transient-receptor-potential calcium channel protein

pfam08344
Location:227 → 286

TRP_2; Transient receptor ion channel II

pfam17075
Location:778 → 892

RRT14; Regular of rDNA transcription protein 14

sd00045
Location:118 → 147

ANK; ANK repeat [structural motif]
NM_165169.5 → NP_723983.1 transient receptor potential cation channel gamma, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_723983.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0S8, Q9N6L1, Q9VJJ7

Related

FBpp0080499

Conserved Domains (5) summary

cd00204
Location:52 → 156

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:16 → 780

trp; transient-receptor-potential calcium channel protein

pfam08344
Location:166 → 225

TRP_2; Transient receptor ion channel II

pfam17075
Location:717 → 832

RRT14; Regular of rDNA transcription protein 14

sd00045
Location:57 → 86

ANK; ANK repeat [structural motif]
NM_135958.5 → NP_609802.1 transient receptor potential cation channel gamma, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609802.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V0S8, Q9N6L1, Q9VJJ7

Related

FBpp0080498

Conserved Domains (5) summary

cd00204
Location:52 → 156

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

TIGR00870
Location:16 → 780

trp; transient-receptor-potential calcium channel protein

pfam08344
Location:166 → 225

TRP_2; Transient receptor ion channel II

pfam17075
Location:717 → 832

RRT14; Regular of rDNA transcription protein 14

sd00045
Location:57 → 86

ANK; ANK repeat [structural motif]