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    ND-51L2 NADH dehydrogenase (ubiquinone) 51 kDa subunit-like 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36695, updated on 27-Dec-2024

    Summary

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    Official Symbol
    ND-51L2provided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) 51 kDa subunit-like 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0034007
    Locus tag
    Dmel_CG8102
    See related
    AllianceGenome:FB:FBgn0034007
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8102; Dmel\CG8102; dNDUFV1C; NUBM
    Summary
    Predicted to enable 4 iron, 4 sulfur cluster binding activity. Predicted to be involved in mitochondrial electron transport, NADH to ubiquinone. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex I. Is expressed in spermatozoon. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ND-51L2 in Genome Data Viewer
    Location:
    51F3-51F4; 2-74 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15296764..15298329, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11184269..11185834, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Integrin alphaPS4 subunit Neighboring gene Transient receptor potential cation channel, subfamily M Neighboring gene long non-coding RNA:CR44241 Neighboring gene uncharacterized protein Neighboring gene Xeroderma pigmentosum, complementation group C Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Roles for Mitochondrial Complex I Subunits in Regulating Synaptic Transmission and Growth. Mallik B, et al. Front Neurosci, 2022. PMID 35557603, Free PMC Article
    2. Evolution of nuclearly encoded mitochondrial genes in Metazoa. De Grassi A, et al. Gene, 2005 Jul 18. PMID 15975737
    3. Insights from Drosophila on mitochondrial complex I. Rhooms SK, et al. Cell Mol Life Sci, 2020 Feb. PMID 31485716, Free PMC Article
    4. Regulation of Mitochondrial Complex I Biogenesis in Drosophila Flight Muscles. Garcia CJ, et al. Cell Rep, 2017 Jul 5. PMID 28683319, Free PMC Article
    5. Genomic mapping of Suppressor of Hairy-wing binding sites in Drosophila. Adryan B, et al. Genome Biol, 2007. PMID 17705839, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADH dehydrogenase (ubiquinone) activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial electron transport, NADH to ubiquinone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) 51 kDa subunit-like 2
    Names
    CG8102-PA
    CG8102-PB
    NADH-UBIQUINONE OXIDOREDUCTASE 51 KDA SUBUNIT
    NADH:ubiquinone oxidoreductase 51 kDa subunit
    ND-51L2-PA
    ND-51L2-PB
    NP_611027.1
    NP_725449.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      15296764..15298329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137183.1 → NP_611027.1  NADH dehydrogenase (ubiquinone) 51 kDa subunit-like 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611027.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9Z6, Q8T495
      Related
      FBpp0086525, FBtr0087393
      Conserved Domains (4) summary
      PTZ00304
      Location:55 → 458
      PTZ00304; NADH dehydrogenase [ubiquinone] flavoprotein 1; Provisional
      pfam01512
      Location:108 → 256
      Complex1_51K; Respiratory-chain NADH dehydrogenase 51 Kd subunit
      pfam10531
      Location:279 → 325
      SLBB; SLBB domain
      pfam10589
      Location:370 → 447
      NADH_4Fe-4S; NADH-ubiquinone oxidoreductase-F iron-sulfur binding region

    2. NM_166086.1 → NP_725449.1  NADH dehydrogenase (ubiquinone) 51 kDa subunit-like 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725449.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z9Z7, Q8T495
      Related
      FBpp0086526, FBtr0087394
      Conserved Domains (4) summary
      PTZ00304
      Location:55 → 477
      PTZ00304; NADH dehydrogenase [ubiquinone] flavoprotein 1; Provisional
      pfam01512
      Location:103 → 275
      Complex1_51K; Respiratory-chain NADH dehydrogenase 51 Kd subunit
      pfam10531
      Location:298 → 335
      SLBB; SLBB domain
      pfam10589
      Location:389 → 466
      NADH_4Fe-4S; NADH-ubiquinone oxidoreductase-F iron-sulfur binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A1Z9Z6 A1Z9Z6
    A1Z9Z7 A1Z9Z7
    Q8T495 Q8T495

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