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    Spt3 Spt3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41461, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spt3provided by FlyBase
    Official Full Name
    Spt3provided by FlyBase
    Primary source
    FLYBASE:FBgn0037981
    Locus tag
    Dmel_CG3169
    See related
    AllianceGenome:FB:FBgn0037981
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3169; Dmel\CG3169; dSpt3; SPT3; TFIID
    Summary
    Predicted to enable transcription coactivator activity. Predicted to be involved in transcription by RNA polymerase II. Located in nucleus. Part of SAGA complex. Orthologous to human SUPT3H (SPT3 homolog, SAGA and STAGA complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Spt3 in Genome Data Viewer
    Location:
    87A5-87A5; 3-51 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12017156..12018550)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7842878..7844272)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Kelch like family member 18 Neighboring gene GRIP and coiled-coil domain containing 185 kDa Neighboring gene DDB1 and CUL4 associated factor 12 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene short spindle 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enzymatic modules of the SAGA chromatin-modifying complex play distinct roles in Drosophila gene expression and development. Li X, et al. Genes Dev, 2017 Aug 1. PMID 28887412, Free PMC Article
    2. The Drosophila Dbf4 ortholog Chiffon forms a complex with Gcn5 that is necessary for histone acetylation and viability. Torres-Zelada EF, et al. J Cell Sci, 2019 Jan 16. PMID 30559249, Free PMC Article
    3. Host cell factor and an uncharacterized SANT domain protein are stable components of ATAC, a novel dAda2A/dGcn5-containing histone acetyltransferase complex in Drosophila. Guelman S, et al. Mol Cell Biol, 2006 Feb. PMID 16428443, Free PMC Article
    4. Two Drosophila Ada2 homologues function in different multiprotein complexes. Kusch T, et al. Mol Cell Biol, 2003 May. PMID 12697829, Free PMC Article
    5. Identification of EMS-induced mutations in Drosophila melanogaster by whole-genome sequencing. Blumenstiel JP, et al. Genetics, 2009 May. PMID 19307605, Free PMC Article

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of SAGA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Spt3
    Names
    CG3169-PA
    Spt3-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      12017156..12018550
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141889.4 → NP_650146.1  Spt3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650146.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29R40, Q9VGE2
      Related
      FBpp0082011
      Conserved Domains (1) summary
      cd07978
      Location:99 → 190
      TAF13; The TATA Binding Protein (TBP) Associated Factor 13 (TAF13) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8I8U9 Q8I8U9
    Q9VGE2 Q9VGE2

    Gene LinkOut

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