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    CG17493 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355126, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG17493provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040010
    Locus tag
    Dmel_CG17493
    See related
    AllianceGenome:FB:FBgn0040010
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG40016; Dmel\CG17493
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in centriole replication. Predicted to be active in centriole; centrosome; and nucleus. Is expressed in larval ventral nerve cord and organism. Orthologous to several human genes including CETN1 (centrin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG17493 in Genome Data Viewer
    Location:
    40F7-40F7; 2-54 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (22550064..22556295)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22442796..22449027)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene long non-coding RNA:CR46268 Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L5 Neighboring gene Sarcolemma associated protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43927

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of heterochromatic genes of Drosophila. Yasuhara JC, et al. Proc Natl Acad Sci U S A, 2005 Aug 2. PMID 16033869, Free PMC Article
    2. The Green Valley of Drosophila melanogaster Constitutive Heterochromatin: Protein-Coding Genes Involved in Cell Division Control. Messina G, et al. Cells, 2022 Sep 29. PMID 36231024, Free PMC Article
    3. The Recent De Novo Origin of Protein C-Termini. Andreatta ME, et al. Genome Biol Evol, 2015 May 21. PMID 26002864, Free PMC Article
    4. A Balance of Yki/Sd Activator and E2F1/Sd Repressor Complexes Controls Cell Survival and Affects Organ Size. Zhang P, et al. Dev Cell, 2017 Dec 4. PMID 29207260, Free PMC Article
    5. Thirteen is enough: the myosins of Dictyostelium discoideum and their light chains. Kollmar M. BMC Genomics, 2006 Jul 20. PMID 16857047, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in centriole replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG17493-PB
    CG17493-PC
    CG17493-PD
    CentrinB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      22550064..22556295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273763.1 → NP_001260692.1  uncharacterized protein Dmel_CG17493, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260692.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGG8
      Conserved Domains (2) summary
      PTZ00183
      Location:26 → 182
      PTZ00183; centrin; Provisional
      cd00051
      Location:115 → 177
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. NM_001273764.1 → NP_001260693.1  uncharacterized protein Dmel_CG17493, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260693.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGG8
      Conserved Domains (2) summary
      PTZ00183
      Location:26 → 182
      PTZ00183; centrin; Provisional
      cd00051
      Location:115 → 177
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    3. NM_001042931.3 → NP_001036396.2  uncharacterized protein Dmel_CG17493, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036396.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PGG8
      Conserved Domains (2) summary
      PTZ00183
      Location:26 → 182
      PTZ00183; centrin; Provisional
      cd00051
      Location:115 → 177
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PGG8 M9PGG8
    Q8SXJ8 Q8SXJ8

    Gene LinkOut

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