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    RasGAP1 Ras GTPase activating protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39158, updated on 27-Dec-2024

    Summary

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    Official Symbol
    RasGAP1provided by FlyBase
    Official Full Name
    Ras GTPase activating protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0004390
    Locus tag
    Dmel_CG6721
    See related
    AllianceGenome:FB:FBgn0004390
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6721; Dmel\CG6721; FBpp0076097; gap; Gap; GAP; Gap 1; gap1; Gap1; GAP1; mip; Ras-GAP; rasGAP; RasGAP; RasGap1; rI533; sxt
    Summary
    Involved in several processes, including negative regulation of cell size; negative regulation of signal transduction; and positive regulation of R7 cell differentiation. Located in plasma membrane. Is expressed in several structures, including central nervous system; imaginal disc; longitudinal trunk visceral muscle primordium; somatic trunk mesoderm; and visceral trunk mesoderm. Human ortholog(s) of this gene implicated in Noonan syndrome. Orthologous to human RASA2 (RAS p21 protein activator 2) and RASA3 (RAS p21 protein activator 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See RasGAP1 in Genome Data Viewer
    Location:
    67C10-67C11; 3-31 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9839093..9855285, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9832193..9848385, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Inhibitor-2 Neighboring gene Cyclin-dependent kinase 8 Neighboring gene uncharacterized protein Neighboring gene calcium-independent phospholipase A2 VIA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bridging the GAP in inositol 1,3,4,5-tetrakisphosphate signalling. Cullen PJ. Biochim Biophys Acta, 1998 Dec 8. PMID 9838034
    2. In vivo functional analysis of Drosophila Gap1: involvement of Ca2+ and IP4 regulation. Powe AC Jr, et al. Mech Dev, 1999 Mar. PMID 10330487
    3. Down-regulation of Drosophila Egf-r mRNA levels following hyperactivated receptor signaling. Sturtevant MA, et al. Development, 1994 Sep. PMID 7956834
    4. The division abnormally delayed (dally) gene: a putative integral membrane proteoglycan required for cell division patterning during postembryonic development of the nervous system in Drosophila. Nakato H, et al. Development, 1995 Nov. PMID 8582281
    5. Competition and position-dependent targeting in the development of the Drosophila R7 visual projections. Ashley JA, et al. Development, 1994 Jun. PMID 8050361

    See all (198) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Drosophila melanogaster Rab GAP RN-tre cross-talks with the Rho1 signaling pathway to regulate nonmuscle myosin II localization and function.
      Title: The Drosophila melanogaster Rab GAP RN-tre cross-talks with the Rho1 signaling pathway to regulate nonmuscle myosin II localization and function.
    2. the Ras/MEK/MAPK pathway regulates regional-fate specification via HSPGs during development
      Title: Ras/MEK/MAPK-mediated regulation of heparin sulphate proteoglycans promotes retinal fate in the Drosophila eye-antennal disc.
    3. the PlexA GAP domain is phosphorylated by the cAMP-dependent protein kinase (PKA). This PlexA phosphorylation generates a specific binding site for 14-3-3epsilon, a phospho-binding protein that we find to be necessary for axon guidance
      Title: 14-3-3ε couples protein kinase A to semaphorin signaling and silences plexin RasGAP-mediated axonal repulsion.
    4. Neurofibromatosis type 1 (NF1) is among the most common genetic disorders of humans and is caused by loss of neurofibromin, a large and highly conserved protein whose only known function is to serve as a GTPase-Activating Protein (GAP) for Ras.
      Title: Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in anterior/posterior axis specification, embryo TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in imaginal disc-derived wing morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of R7 cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of sevenless signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of torso signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of torso signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of R7 cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ras GTPase activating protein 1
    Names
    CG6721-PA
    CG6721-PB
    CG6721-PC
    GTPase activating protein 1
    GTPase activating protein1
    GTPase-activating protein 1
    RasGAP1-PA
    RasGAP1-PB
    RasGAP1-PC
    more inner photoreceptors
    seven extra
    sextra

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9839093..9855285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168382.2 → NP_729562.1  Ras GTPase activating protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729562.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1S6, P48423, Q6NP17, Q9VT58
      Related
      FBpp0076097
      Conserved Domains (7) summary
      smart00107
      Location:862 → 897
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:280 → 462
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:44 → 169
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cd05128
      Location:473 → 740
      RasGAP_GAP1_like; Ras-GTPase Activating Domain of GAP1 and similar proteins
      smart00323
      Location:449 → 797
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd01244
      Location:763 → 867
      PH_GAP1-like; RAS p21 protein activator (GTPase activating protein) family pleckstrin homology (PH) domain
      pfam00169
      Location:761 → 859
      PH; PH domain

    2. NM_079290.3 → NP_524014.2  Ras GTPase activating protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524014.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1S6, P48423, Q6NP17, Q9VT58
      Related
      FBpp0076096
      Conserved Domains (7) summary
      smart00107
      Location:862 → 897
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:280 → 462
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:44 → 169
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cd05128
      Location:473 → 740
      RasGAP_GAP1_like; Ras-GTPase Activating Domain of GAP1 and similar proteins
      smart00323
      Location:449 → 797
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd01244
      Location:763 → 867
      PH_GAP1-like; RAS p21 protein activator (GTPase activating protein) family pleckstrin homology (PH) domain
      pfam00169
      Location:761 → 859
      PH; PH domain

    3. NM_001274735.1 → NP_001261664.1  Ras GTPase activating protein 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261664.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PF62
      Conserved Domains (7) summary
      smart00107
      Location:862 → 897
      BTK; Bruton's tyrosine kinase Cys-rich motif
      cd04010
      Location:280 → 462
      C2B_RasA3; C2 domain second repeat present in RAS p21 protein activator 3 (RasA3)
      cd08401
      Location:44 → 169
      C2A_RasA2_RasA3; C2 domain first repeat present in RasA2 and RasA3
      cd05128
      Location:473 → 740
      RasGAP_GAP1_like; Ras-GTPase Activating Domain of GAP1 and similar proteins
      smart00323
      Location:449 → 797
      RasGAP; GTPase-activator protein for Ras-like GTPases
      cd01244
      Location:763 → 867
      PH_GAP1-like; RAS p21 protein activator (GTPase activating protein) family pleckstrin homology (PH) domain
      pfam00169
      Location:761 → 859
      PH; PH domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PF62 M9PF62
    P48423.2 P48423

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