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    CG8916 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32553, updated on 27-Dec-2024

    Summary

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    Official Symbol
    CG8916provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030707
    Locus tag
    Dmel_CG8916
    See related
    AllianceGenome:FB:FBgn0030707
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8916; Lcch-14A
    Summary
    Predicted to enable GABA-A receptor activity and extracellular ligand-gated monoatomic ion channel activity. Predicted to contribute to chloride channel activity. Predicted to be involved in chloride transmembrane transport. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; alcoholic liver cirrhosis; amphetamine abuse; and epilepsy (multiple). Orthologous to several human genes including GABRA3 (gamma-aminobutyric acid type A receptor subunit alpha3); GABRA4 (gamma-aminobutyric acid type A receptor subunit alpha4); and GABRA5 (gamma-aminobutyric acid type A receptor subunit alpha5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8916 in Genome Data Viewer
    Location:
    14A1-14A1; 1-52 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (15921955..15924558)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (15815988..15818591)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Cyclin D Neighboring gene LDL receptor related protein 4 Neighboring gene antisense RNA:CR45000 Neighboring gene Ligand-gated chloride channel homolog 3 Neighboring gene Ranbp16

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence for a diverse Cys-loop ligand-gated ion channel superfamily in early bilateria. Dent JA. J Mol Evol, 2006 May. PMID 16586016
    2. Two cDNAs coding for histamine-gated ion channels in D. melanogaster. Gisselmann G, et al. Nat Neurosci, 2002 Jan. PMID 11753412
    3. A novel chloride channel in Drosophila melanogaster is inhibited by protons. Schnizler K, et al. J Biol Chem, 2005 Apr 22. PMID 15713676
    4. Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1. Lee WS, et al. J Clin Invest, 2022 May 2. PMID 35499073, Free PMC Article
    5. Evolution, Expression, and Function of Nonneuronal Ligand-Gated Chloride Channels in Drosophila melanogaster. Remnant EJ, et al. G3 (Bethesda), 2016 Jul 7. PMID 27172217, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GABA-A receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to chloride channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables extracellular ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8916-PB
    CG8916-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      15921955..15924558
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_132862.3 → NP_573090.3  uncharacterized protein Dmel_CG8916, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573090.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V4V5, Q9VXL9
      Conserved Domains (3) summary
      TIGR00860
      Location:92 → 598
      LIC; Cation transporter family protein
      pfam02931
      Location:111 → 315
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:322 → 403
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

    2. NM_001169299.2 → NP_001162770.1  uncharacterized protein Dmel_CG8916, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162770.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JJA9, Q4V4W7
      Conserved Domains (3) summary
      TIGR00860
      Location:9 → 496
      LIC; Cation transporter family protein
      pfam02931
      Location:9 → 213
      Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
      pfam02932
      Location:220 → 301
      Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JJA9 E1JJA9
    Q9VXL9 Q9VXL9

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