p53 p53 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: p53provided by FlyBase
Official Full Name: p53provided by FlyBase
Primary source: FLYBASE:FBgn0039044
Locus tag: Dmel_CG33336
See related: AllianceGenome:FB:FBgn0039044
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10873; CG31325; CG33336; D-p53; Dm-P53; Dmel\CG33336; dmp53; dmP53; Dmp53; DmP53; DMP53; dp53; Dp53; P53; prac
Summary: Enables several functions, including TFIIH-class transcription factor complex binding activity; enzyme binding activity; and promoter-specific chromatin binding activity. Involved in several processes, including cellular response to gamma radiation; generation of neurons; and positive regulation of metabolic process. Located in nucleus. Colocalizes with chromocenter and euchromatin. Is expressed in several structures, including embryonic/larval midgut primordium; foregut primordium; germline cell; gut section; and hindgut proper primordium. Used to study cancer and testicular cancer. Human ortholog(s) of this gene implicated in several diseases, including EEC syndrome (multiple); Li-Fraumeni syndrome (multiple); carcinoma (multiple); ectodermal dysplasia (multiple); and hematologic cancer (multiple). Orthologous to several human genes including TP53 (tumor protein p53). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 94D10-94D10; 3-77 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (23049657..23054082, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (18875379..18879804, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Nuclear reassembly defects after mitosis trigger apoptotic and p53-dependent safeguard mechanisms in Drosophila.
Title: Nuclear reassembly defects after mitosis trigger apoptotic and p53-dependent safeguard mechanisms in Drosophila.
Association of Hsp90 with p53 and Fizzy related homolog (Fzr) synchronizing Anaphase Promoting Complex (APC/C): An unexplored ally towards oncogenic pathway.
Title: Association of Hsp90 with p53 and Fizzy related homolog (Fzr) synchronizing Anaphase Promoting Complex (APC/C): An unexplored ally towards oncogenic pathway.
Distinct p53 isoforms code for opposing transcriptional outcomes.
Title: Distinct p53 isoforms code for opposing transcriptional outcomes.
Cooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance.
Title: Cooperation between oncogenic Ras and wild-type p53 stimulates STAT non-cell autonomously to promote tumor radioresistance.
VCP maintains nuclear size by regulating the DNA damage-associated MDC1-p53-autophagy axis in Drosophila.
Title: VCP maintains nuclear size by regulating the DNA damage-associated MDC1-p53-autophagy axis in Drosophila.
Cells with loss-of-heterozygosity after exposure to ionizing radiation in Drosophila are culled by p53-dependent and p53-independent mechanisms.
Title: Cells with loss-of-heterozygosity after exposure to ionizing radiation in Drosophila are culled by p53-dependent and p53-independent mechanisms.
Role of p53 isoforms in the DNA damage response during Drosophila oogenesis.
Title: Role of p53 isoforms in the DNA damage response during Drosophila oogenesis.
The differential use of p53 isoforms combined with the antagonism between apoptosis and autophagy ensures the generation of an appropriate p53 biological response to stress.
Title: Drosophila p53 integrates the antagonism between autophagy and apoptosis in response to stress.
The cell interactions that lead to cell competition may depend on pathways that can be activated by p53 in both mammals and in Drosophila.
Title: A potential link between p53, cell competition and ribosomopathy in mammals and in Drosophila.
observations support the critical role for p53 in conferring tolerance of transposable element activity in stem cells.
Title: p53 is required for female germline stem cell maintenance in P-element hybrid dysgenesis.

Submit: New GeneRIF Correction See all GeneRIFs (59)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II general transcription initiation factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables TFIIH-class transcription factor complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in DNA damage response, signal transduction by p53 class mediator	TAS Traceable Author Statement more info	PubMed
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to gamma radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ectopic germ cell programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	TAS Traceable Author Statement more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of insulin-like growth factor receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of photoreceptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cellular response to X-ray	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of growth rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of programmed necrotic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reciprocal meiotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA repair	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of apoptosis involved in tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of organ growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in response to UV	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ionizing radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to radiation	TAS Traceable Author Statement more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue regeneration	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
colocalizes_with chromocenter	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with euchromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: p53

Names: CG33336-PA; CG33336-PB; CG33336-PC; CG33336-PE; Dmp53; drosophila p53; p53-PA; p53-PB; p53-PC; p53-PE; p53-like regulator of apoptosis and cell cycle; protein 53

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

23049657..23054082 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_206544.2 → NP_996267.1 p53, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996267.1

Status: REVIEWED

UniProtKB/TrEMBL

Q2XVY7, Q8IMZ4

Conserved Domains (2) summary

cd08367
Location:203 → 383

P53; P53 DNA-binding domain

pfam11619
Location:429 → 495

P53_C; Transcription factor P53 - C terminal domain
NM_001170223.1 → NP_001163694.1 p53, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001163694.1

Status: REVIEWED

UniProtKB/TrEMBL

D5AEJ5, Q9N6D8, Q9VCR8

Conserved Domains (2) summary

cd08367
Location:93 → 273

P53; P53 DNA-binding domain

pfam11619
Location:319 → 385

P53_C; Transcription factor P53 - C terminal domain
NM_206545.2 → NP_996268.1 p53, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996268.1

Status: REVIEWED

UniProtKB/TrEMBL

D5AEJ5, Q9N6D8, Q9VCR8

Conserved Domains (2) summary

cd08367
Location:93 → 273

P53; P53 DNA-binding domain

pfam11619
Location:319 → 385

P53_C; Transcription factor P53 - C terminal domain
NM_001260323.2 → NP_001247252.2 p53, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001247252.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4K7P1, D5AEJ5

Conserved Domains (2) summary

cd08367
Location:42 → 222

P53; P53 DNA-binding domain

pfam11619
Location:268 → 334

P53_C; Transcription factor P53 - C terminal domain