srl spargel [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: srlprovided by FlyBase
Official Full Name: spargelprovided by FlyBase
Primary source: FLYBASE:FBgn0037248
Locus tag: Dmel_CG9809
See related: AllianceGenome:FB:FBgn0037248
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG 9809; cg9809; CG9809; dh-PPRC1; Dmel\CG9809; DmPGC-1; DmPGC-1/spargel; DmPGC-1alpha; dPCG1alpha; dPGC; dPGC-1; dPGC-1alpha; dPGC1; PCG1-alpha; PGC-1; PGC-1-alpha; PGC-1alpha; PGC1; PGC1-alpha; PGC1a; Spargel; Srl
Summary: Predicted to enable mRNA binding activity and nuclear receptor coactivator activity. Involved in several processes, including cellular response to insulin stimulus; negative regulation of insulin receptor signaling pathway; and positive regulation of oxidative phosphorylation. Located in cytosol and nuclear speck. Is expressed in several structures, including adult gnathal ganglion; embryonic/larval midgut primordium; larval somatic muscle cell; mesoderm; and visceral mesoderm derivative. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including malignant fibrous histiocytoma; metabolic dysfunction-associated steatotic liver disease; neurodegenerative disease (multiple); obesity; and type 2 diabetes mellitus. Orthologous to several human genes including PPARGC1A (PPARG coactivator 1 alpha) and PPRC1 (PPARG related coactivator 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 82B1-82B1; 3-47.1 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (4422483..4429335, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (248205..255057, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Maternal Spargel/dPGC-1 is critical for embryonic development and influences chorion gene amplification via Cyclin E activity.
Title: Maternal Spargel/dPGC-1 is critical for embryonic development and influences chorion gene amplification via Cyclin E activity.
New mutant alleles for Spargel/dPGC-1 highlights the function of Spargel RRM domain in oogenesis and expands the role of Spargel in embryogenesis and intracellular transport.
Title: New mutant alleles for Spargel/dPGC-1 highlights the function of Spargel RRM domain in oogenesis and expands the role of Spargel in embryogenesis and intracellular transport.
PGC1alpha Controls Sucrose Taste Sensitization in Drosophila.
Title: PGC1α Controls Sucrose Taste Sensitization in Drosophila.
srl has a more general role in early development than specifically promoting mitochondrial biogenesis.
Title: Germline knockdown of spargel (PGC-1) produces embryonic lethality in Drosophila.
Muscle-specific knockdown of spargel protein (dPGC-1) reverses the effects of muscle-specific knockdown of CG17019 (dRNF34).
Title: RNF34 modulates the mitochondrial biogenesis and exercise capacity in muscle and lipid metabolism through ubiquitination of PGC-1 in Drosophila.
Genetic or pharmacological activation of PGC-1a may be of therapeutic value to Parkinson's disease.
Title: Genetic or pharmacological activation of the Drosophila PGC-1α ortholog spargel rescues the disease phenotypes of genetic models of Parkinson's disease.
The reduced lifespan and climbing ability associated with a tissue specific expression of srl in DA neurons provides a new model of PD in D. melanogaster.
Title: spargel, the PGC-1α homologue, in models of Parkinson disease in Drosophila melanogaster.
Our data suggest INDY may be a physiological regulator that modulates intermediary metabolism in response to changes in nutrient availability and organismal needs by modulating dPGC-1.
Title: Increased mitochondrial biogenesis preserves intestinal stem cell homeostasis and contributes to longevity in Indy mutant flies.
This led us to conclude that Spargel should be incorporated as a new member of this growth-signaling pathway
Title: Spargel/dPGC-1 is a new downstream effector in the insulin-TOR signaling pathway in Drosophila.
dPGC-1 (spargel) can slow aging both at the level of cellular changes in an individual tissue and also at the organismal level by extending life span.
Title: Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables nuclear receptor coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to insulin stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in energy homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron cellular homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oxidative phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: spargel

Names: CG9809-PB; CG9809-PD; CG9809-PE; PGC-1/spargel; PPARG coactivator 1alpha; PPARGC1A; peroxisome proliferator-activated receptor gamma coactivator 1; peroxisome proliferator-activated receptor gamma coactivator-1alpha; srl-PB; srl-PD; srl-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

4422483..4429335 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_168996.5 → NP_730835.2 spargel, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730835.2

Status: REVIEWED

UniProtKB/TrEMBL

Q6NPA7, Q8IPM1

Related

FBpp0078586

Conserved Domains (2) summary

COG0724
Location:906 → 975

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12357
Location:914 → 1002

RRM_PPARGC1A_like; RNA recognition motif in the peroxisome proliferator-activated receptor gamma coactivator 1A (PGC-1alpha) family of regulated coactivators
NM_168997.5 → NP_730836.3 spargel, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730836.3

Status: REVIEWED

UniProtKB/TrEMBL

Q5U183, Q8IPM0

Conserved Domains (2) summary

COG0724
Location:897 → 966

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12357
Location:905 → 993

RRM_PPARGC1A_like; RNA recognition motif in the peroxisome proliferator-activated receptor gamma coactivator 1A (PGC-1alpha) family of regulated coactivators
NM_141212.4 → NP_649469.2 spargel, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_649469.2

Status: REVIEWED

UniProtKB/TrEMBL

Q6NPA7, Q8IPM1

Conserved Domains (2) summary

COG0724
Location:906 → 975

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12357
Location:914 → 1002

RRM_PPARGC1A_like; RNA recognition motif in the peroxisome proliferator-activated receptor gamma coactivator 1A (PGC-1alpha) family of regulated coactivators