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    Sptr Sepiapterin reductase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31781, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sptrprovided by FlyBase
    Official Full Name
    Sepiapterin reductaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0014032
    Locus tag
    Dmel_CG12117
    See related
    AllianceGenome:FB:FBgn0014032
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12117; Dmel\CG12117; sptr; SR
    Summary
    Enables sepiapterin reductase (NADP+) activity. Predicted to be involved in tetrahydrobiopterin biosynthetic process. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in dystonia and sepiapterin reductase deficiency. Orthologous to human SPR (sepiapterin reductase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sptr in Genome Data Viewer
    Location:
    7E11-7E11; 1-23 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8463296..8464438, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8357329..8358471, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Es2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Chorion protein a at 7F

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutagenesis by imprecise excision of the piggyBac transposon in Drosophila melanogaster. Kim H, et al. Biochem Biophys Res Commun, 2012 Jan 6. PMID 22155246
    2. Structure, chromosomal localization, and expression of the Drosophila melanogaster gene encoding sepiapterin reductase. Seong C, et al. Gene, 2000 Sep 19. PMID 11024296
    3. Partial purification and some properties of biopterin synthase and dihydropterin oxidase from Drosophila melanogaster. Fan CL, et al. Biochem Genet, 1979 Apr. PMID 114164
    4. Sepiapterin reductase and the biosynthesis of tetrahydrobiopterin in Drosophila melanogaster. Primus JP, et al. Insect Biochem Mol Biol, 1994 Oct. PMID 7951268
    5. WSV056 Inhibits Shrimp Nitric Oxide Synthase Activity by Downregulating Litopenaeus vannamei Sepiapterin Reductase to Promote White Spot Syndrome Virus Replication. Wang W, et al. Front Microbiol, 2021. PMID 35003027, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables sepiapterin reductase (NADP+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sepiapterin reductase (NADP+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sepiapterin reductase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tetrahydrobiopterin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tetrahydrobiopterin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sepiapterin reductase
    Names
    CG12117-PA
    Sptr-PA
    NP_727265.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8463296..8464438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167157.2 → NP_727265.1  sepiapterin reductase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727265.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B4F5K6, B4F5L3, C0MLI5, O76752
      Related
      FBpp0071184
      Conserved Domains (2) summary
      TIGR01500
      Location:7 → 258
      sepiapter_red; sepiapterin reductase
      pfam00106
      Location:10 → 204
      adh_short; short chain dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O76752 O76752

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