tio tiptop [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: tioprovided by FlyBase
Official Full Name: tiptopprovided by FlyBase
Primary source: FLYBASE:FBgn0028979
Locus tag: Dmel_CG12630
See related: AllianceGenome:FB:FBgn0028979
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12630; Dmel\CG12630; Tio
Summary: Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including Malpighian tubule stellate cell differentiation; epidermis morphogenesis; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in embryonic specialized Malpighian tubule cell; eye disc anterior to the morphogenetic furrow; and imaginal disc. Orthologous to human TSHZ1 (teashirt zinc finger homeobox 1); TSHZ2 (teashirt zinc finger homeobox 2); and TSHZ3 (teashirt zinc finger homeobox 3). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (22019208..22025734)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (22019208..22025734)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Tiptop/teashirt genes regulate cell differentiation and renal physiology in Drosophila.
Title: The tiptop/teashirt genes regulate cell differentiation and renal physiology in Drosophila.
Tio has four such Zinc Finger domains Tio bind to C-terminal Binding Protein (CtBP) and that this interaction is important for promoting both cell proliferation and eye development.
Title: A dissection of the teashirt and tiptop genes reveals a novel mechanism for regulating transcription factor activity.
Data show that tiptop appears to be a more effective inducer of retinal formation than teashirt.
Title: Restriction of ectopic eye formation by Drosophila teashirt and tiptop to the developing antenna.
Data show that tio (tiptop) and tsh (teashirt) have coincident expression domains in the imaginal discs, the precursors of the adult body, and that both genes show similar functional properties when expressed ectopically.
Title: Zinc-finger paralogues tsh and tio are functionally equivalent during imaginal development in Drosophila and maintain their expression levels through auto- and cross-negative feedback loops.
Teashirt and Tiptop repress each other's expression
Title: A critical role of teashirt for patterning the ventral epidermis is masked by ectopic expression of tiptop, a paralog of teashirt in Drosophila.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Malpighian tubule stellate cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in Malpighian tubule stellate cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epidermis morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in specification of segmental identity, head	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain