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    Rbp1-like Rbp1-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32293, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbp1-likeprovided by FlyBase
    Official Full Name
    Rbp1-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030479
    Locus tag
    Dmel_CG1987
    See related
    AllianceGenome:FB:FBgn0030479
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE47308; BEST:HL02433; CG1987; Dmel\CG1987; i159; RBP1-like; Rbp1L
    Summary
    Enables mRNA binding activity. Involved in RNA splicing and regulation of RNA metabolic process. Part of precatalytic spliceosome. Is expressed in adult heart and organism. Orthologous to human SRSF3 (serine and arginine rich splicing factor 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rbp1-like in Genome Data Viewer
    Location:
    11F1-11F1; 1-43 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13380166..13384877, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13274199..13278910, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene doublesex-Mab related 11E Neighboring gene uncharacterized protein Neighboring gene Tim9a Neighboring gene Yippee

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The SR proteins SF2 and RBP1 regulate triglyceride storage in the fat body of Drosophila. Bennick RA, et al. Biochem Biophys Res Commun, 2019 Aug 27. PMID 31277943
    2. The SR protein B52/SRp55 regulates splicing of the period thermosensitive intron and mid-day siesta in Drosophila. Zhang Z, et al. Sci Rep, 2018 Jan 30. PMID 29382842, Free PMC Article
    3. Negative feedback regulation among SR splicing factors encoded by Rbp1 and Rbp1-like in Drosophila. Kumar S, et al. EMBO J, 2005 Jul 20. PMID 15961996, Free PMC Article
    4. Genetic variation in the Yolk protein expression network of Drosophila melanogaster: sex-biased negative correlations with longevity. Tarone AM, et al. Heredity (Edinb), 2012 Oct. PMID 22760232, Free PMC Article
    5. A regulator of Dscam mutually exclusive splicing fidelity. Olson S, et al. Nat Struct Mol Biol, 2007 Dec. PMID 21188797, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rbp1-like negatively autoregulates and crossregulates at the level of alternative 3' splice site selection.
      Title: Negative feedback regulation among SR splicing factors encoded by Rbp1 and Rbp1-like in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA cis splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcriptional start site selection at RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    Rbp1-like
    Names
    CG1987-PA
    CG1987-PB
    CG1987-PC
    Rbp1-like-PA
    Rbp1-like-PB
    Rbp1-like-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      13380166..13384877 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298278.1 → NP_001285207.1  Rbp1-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285207.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYD8
      Conserved Domains (2) summary
      COG0724
      Location:11 → 81
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12373
      Location:12 → 81
      RRM_SRSF3_like; RNA recognition motif in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins

    2. NM_132652.4 → NP_572880.2  Rbp1-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572880.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VYD8
      Related
      FBpp0073621
      Conserved Domains (2) summary
      COG0724
      Location:11 → 81
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12373
      Location:12 → 81
      RRM_SRSF3_like; RNA recognition motif in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins

    3. NM_001201656.2 → NP_001188585.1  Rbp1-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188585.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS48
      Conserved Domains (2) summary
      COG0724
      Location:11 → 81
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12373
      Location:12 → 81
      RRM_SRSF3_like; RNA recognition motif in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9MS48 M9MS48
    Q9VYD8 Q9VYD8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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