Fpgs2 Folylpolyglutamate synthase 2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Fpgs2provided by FlyBase
Official Full Name: Folylpolyglutamate synthase 2provided by FlyBase
Primary source: FLYBASE:FBgn0051773
Locus tag: Dmel_CG31773
See related: AllianceGenome:FB:FBgn0051773
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG31773; CG3390; Dmel\CG31773; FBgn0051773
Summary: Predicted to enable tetrahydrofolylpolyglutamate synthase activity. Predicted to be involved in tetrahydrofolylpolyglutamate biosynthetic process. Predicted to be active in cytosol and mitochondrion. Orthologous to human FPGS (folylpolyglutamate synthase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (3911796..3914288, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (3911796..3914288, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables tetrahydrofolylpolyglutamate synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tetrahydrofolylpolyglutamate synthase activity	IEA Inferred from Electronic Annotation more info
enables tetrahydrofolylpolyglutamate synthase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in folic acid-containing compound biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrofolylpolyglutamate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tetrahydrofolylpolyglutamate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

NP_722953.1

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The following sections contain reference sequences that belong to a specific genome build. Explain