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    Nlp Nucleoplasmin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43560, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nlpprovided by FlyBase
    Official Full Name
    Nucleoplasminprovided by FlyBase
    Primary source
    FLYBASE:FBgn0016685
    Locus tag
    Dmel_CG7917
    See related
    AllianceGenome:FB:FBgn0016685
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7917; Crp1; CRP1; dCAF-4; Dmel\CG7917; dNLP; dNLP-S; nlp; NLP; p22
    Summary
    Enables histone binding activity. Involved in chromatin remodeling and sperm DNA decondensation. Located in cytoplasm and nucleolus. Colocalizes with polytene chromosome interband. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; and ganglia. Used to study primary ovarian insufficiency. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to several human genes including NPM3 (nucleophosmin/nucleoplasmin 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nlp in Genome Data Viewer
    Location:
    99D1-99D1; 3-100 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30004785..30010352)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25830507..25836074)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tace Neighboring gene Nucleophosmin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular and cellular characterization of CRP1, a Drosophila chromatin decondensation protein. Crevel G, et al. J Struct Biol, 1997 Feb. PMID 9087911
    2. The crystal structure of Drosophila NLP-core provides insight into pentamer formation and histone binding. Namboodiri VM, et al. Structure, 2003 Feb. PMID 12575937
    3. Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1. Xiao W, et al. Signal Transduct Target Ther, 2021 Apr 16. PMID 33859171, Free PMC Article
    4. Oligomerization of Drosophila Nucleoplasmin-Like Protein is required for its centromere localization. Anselm E, et al. Nucleic Acids Res, 2018 Nov 30. PMID 30357352, Free PMC Article
    5. A simple and versatile system for the ATP-dependent assembly of chromatin. Khuong MT, et al. J Biol Chem, 2017 Nov 24. PMID 28982979, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1.
      Title: Nlp promotes autophagy through facilitating the interaction of Rab7 and FYCO1.
    2. NLP and HMR largely co-localize in domains that are immediately adjacent to, yet distinct from centromere domains defined by the centromeric histone dCENP-A.
      Title: Oligomerization of Drosophila Nucleoplasmin-Like Protein is required for its centromere localization.
    3. NLP is essential for the positioning of centromeres during cell division in Drosophila.
      Title: The nucleoplasmin homolog NLP mediates centromere clustering and anchoring to the nucleolus.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in sperm DNA decondensation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm HDA PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with polytene chromosome interband IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleoplasmin
    Names
    CG7917-PA
    CG7917-PB
    Nlp-PA
    Nlp-PB
    Nucleoplasmin-like
    chromatin decondensation protein 1
    nucleoplasmin-1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30004785..30010352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079833.2 → NP_524557.1  nucleoplasmin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524557.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24565, Q27415, Q540W3, Q9VAC3
      UniProtKB/TrEMBL
      A0A0B4KI24
      Related
      FBpp0084918, FBtr0085552
      Conserved Domains (1) summary
      pfam03066
      Location:6 → 104
      Nucleoplasmin; Nucleoplasmin/nucleophosmin domain

    2. NM_001276165.1 → NP_001263094.1  nucleoplasmin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263094.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24565, Q27415, Q540W3, Q9VAC3
      UniProtKB/TrEMBL
      A0A0B4KI24
      Conserved Domains (1) summary
      pfam03066
      Location:6 → 104
      Nucleoplasmin; Nucleoplasmin/nucleophosmin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KI24 A0A0B4KI24
    Q27415.1 Q27415

    Gene LinkOut

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