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    fwe flower [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39720, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fweprovided by FlyBase
    Official Full Name
    flowerprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261722
    Locus tag
    Dmel_CG6151
    See related
    AllianceGenome:FB:FBgn0261722
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.242; CG6151; dFwe; Dmel\CG6151; drFlower; Fwe
    Summary
    Enables calcium channel activity. Involved in several processes, including cell competition in a multicellular organism; positive regulation of neuron apoptotic process; and synaptic vesicle endocytosis. Located in plasma membrane and synaptic vesicle membrane. Is expressed in several structures, including adult brain cell body rind; adult head; adult heart; brain; and imaginal disc. Orthologous to human CACFD1 (calcium channel flower domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See fwe in Genome Data Viewer
    Location:
    72A1-72A1; 3-43 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15810081..15816410, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15803181..15809510, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene CKII-alpha subunit interactor-1 Neighboring gene Decapping protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Function of Amyloid-β in Mediating Activity-Dependent Axon/Synapse Competition May Unify Its Roles in Brain Physiology and Pathology. Huang Z. J Alzheimers Dis, 2023. PMID 36710681, Free PMC Article
    2. Flower-deficient mice have reduced susceptibility to skin papilloma formation. Petrova E, et al. Dis Model Mech, 2012 Jul. PMID 22362363, Free PMC Article
    3. How to be in a good shape? The influence of clone morphology on cell competition. Levayer R, et al. Commun Integr Biol, 2016 Jan-Feb. PMID 27066183, Free PMC Article
    4. Cytotoxic granule endocytosis depends on the Flower protein. Chang HF, et al. J Cell Biol, 2018 Feb 5. PMID 29288152, Free PMC Article
    5. Cell Fitness: More Than Push-Ups. Ferrari AJ, et al. Int J Mol Sci, 2021 Jan 7. PMID 33430180, Free PMC Article

    See all (96) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cell Fitness: More Than Push-Ups.
      Title: Cell Fitness: More Than Push-Ups.
    2. A positive feedback loop between Flower and PI(4,5)P2 at periactive zones controls bulk endocytosis in Drosophila.
      Title: A positive feedback loop between Flower and PI(4,5)P(2) at periactive zones controls bulk endocytosis in Drosophila.
    3. Fwe promotes clathrin-mediated endocytosis independently of Ca2+channeling.
      Title: A Ca2+ channel differentially regulates Clathrin-mediated and activity-dependent bulk endocytosis.
    4. Our results suggest that Fwe is a component of the cell competition response that is required and sufficient to label cells as "winners" or "losers.&quot.
      Title: Flower forms an extracellular code that reveals the fitness of a cell to its neighbors in Drosophila.
    5. Study reports the identification of a protein that has not been previously characterized in any species and whose loss affects endocytosis. It contains three or four transmembrane domains and is associated with synaptic vesicles.
      Title: A synaptic vesicle-associated Ca2+ channel promotes endocytosis and couples exocytosis to endocytosis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bulk synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell competition in a multicellular organism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in clathrin-dependent synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in photoreceptor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of presynaptic cytosolic calcium concentration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    flower
    Names
    CG6151-PA
    CG6151-PB
    CG6151-PC
    fwe-PA
    fwe-PB
    fwe-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15810081..15816410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140547.5 → NP_648804.1  flower, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648804.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IQM8, Q95T12, Q9VUU2
      Related
      FBpp0075297
      Conserved Domains (1) summary
      smart01077
      Location:36 → 147
      Cg6151-P; Uncharacterized conserved protein CG6151-P

    2. NM_168632.4 → NP_730071.1  flower, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730071.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      D8FT42
      Related
      FBpp0075298
      Conserved Domains (1) summary
      cl10918
      Location:36 → 146
      Cg6151-P; Uncharacterized conserved protein CG6151-P

    3. NM_168633.4 → NP_730072.1  flower, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730072.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAK1
      Related
      FBpp0075296
      Conserved Domains (1) summary
      smart01077
      Location:36 → 147
      Cg6151-P; Uncharacterized conserved protein CG6151-P
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95T12.1 Q95T12

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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