scra scraps [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: scraprovided by FlyBase
Official Full Name: scrapsprovided by FlyBase
Primary source: FLYBASE:FBgn0261385
Locus tag: Dmel_CG2092
See related: AllianceGenome:FB:FBgn0261385
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Abp8; ABP8; ani; Ani; anil; Anil; anillin; Anillin; CG2092; Dmel\CG2092; l(2)03427; l(2)43Ec; l(2)k08255; Scra
Summary: Enables actin filament binding activity; microtubule binding activity; and myosin binding activity. Involved in several processes, including cytoskeleton-dependent cytokinesis; male germline ring canal formation; and pole cell formation. Located in several cellular components, including actomyosin contractile ring; cleavage furrow; and male germline ring canal. Is expressed in several structures, including CNS glial cell; brain; epithelium; head epidermis primordium; and somatic cell of ovariole. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 8. Orthologous to human ANLN (anillin, actin binding protein). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 43E3-43E3; 2-57 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (7590119..7595242)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3477624..3482747)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we show that the transition from the actomyosin contractile ring to the midbody ring proceeds via a previously uncharacterized maturation process that requires opposing mechanisms of removal and retention of the scaffold protein Anillin.
Title: Opposing actions of septins and Sticky on Anillin promote the transition from contractile to midbody ring.
Anillin is required for complete closure of the contractile ring and formation of the midbody ring during cytokinesis.
Title: Anillin acts as a bifunctional linker coordinating midbody ring biogenesis during cytokinesis.
the anillin pleckstrin homology domain has two functions: targeting anillin to the plasma membrane furrow by binding to phosphatidylinositol phosphate lipids to maintain furrow organization and recruiting septins to the furrow.
Title: Cleavage furrow organization requires PIP(2)-mediated recruitment of anillin.
Data suggest that Cindr and Anillin cooperate to promote intercellular bridge stability during incomplete cytokinesis in Drosophila melanogaster.
Title: Cindr interacts with anillin to control cytokinesis in Drosophila melanogaster.
Results show that the anillin-septin and cadherin-catenin complexes can serve as alternative cassettes to promote tight physical coupling of F-actin and myosin II to the cleavage furrow and successful completion of cytokinesis.
Title: Stabilization of the actomyosin ring enables spermatocyte cytokinesis in Drosophila.
anillin and Peanut are involved in pseudocleavage furrow ingression in syncytial embryos, a process that is regulated by Ran
Title: Anillin-mediated targeting of peanut to pseudocleavage furrows is regulated by the GTPase Ran.
interaction with cleavage furrow mediates RacGAP50C's control of actomyosin ring assembly
Title: Interaction between Anillin and RacGAP50C connects the actomyosin contractile ring with spindle microtubules at the cell division site.
A novel RhoGEF(Pbl)-dependent input promotes the simultaneous association of anillin with the plasma membrane, septins, and microtubules, independently of F-actin.
Title: Rho-dependent control of anillin behavior during cytokinesis.
important role for scraps in scaffolding cleavage furrow components, directly stabilizing intracellular bridges
Title: Characterization of anillin mutants reveals essential roles in septin localization and plasma membrane integrity.
anillin has a role in spatially regulating the contractile activity of myosin II during cytokinesis
Title: Anillin binds nonmuscle myosin II and regulates the contractile ring.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0271 (e-PCR)
- UniSTS:22473

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables myosin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actomyosin contractile ring assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in actomyosin contractile ring assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellularization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytokinesis, division site positioning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intercellular bridge organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male germline ring canal formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiosis cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pole cell formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ precursor cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in septin ring organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in septin ring organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in actomyosin contractile ring	IBA Inferred from Biological aspect of Ancestor more info
located_in actomyosin contractile ring	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
located_in contractile ring	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in germline ring canal	IDA Inferred from Direct Assay more info	PubMed
located_in male germline ring canal	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: scraps

Names: Actin-binding protein 8; CG2092-PA; CG2092-PB; CG2092-PC; anillin; annilin; lethal (2) k08255; scra-PA; scra-PB; scra-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

7590119..7595242

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_165543.2 → NP_724582.1 scraps, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724582.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q24240, Q8MKN2, Q8T067, Q9V4P1

Related

FBpp0087986

Conserved Domains (4) summary

cd01263
Location:1106 → 1233

PH_anillin; Anillin Pleckstrin homology (PH) domain

pfam00169
Location:1107 → 1229

PH; PH domain

pfam08174
Location:929 → 1076

Anillin; Cell division protein anillin

pfam16018
Location:153 → 227

Anillin_N; Anillin N-terminus
NM_001014502.2 → NP_001014502.1 scraps, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001014502.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8T0J3

Conserved Domains (1) summary

pfam16018
Location:153 → 227

Anillin_N; Anillin N-terminus
NM_165544.2 → NP_724583.1 scraps, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_724583.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9V4P1

Related

FBpp0087985

Conserved Domains (4) summary

cd01263
Location:1079 → 1206

PH_anillin; Anillin Pleckstrin homology (PH) domain

pfam00169
Location:1080 → 1202

PH; PH domain

pfam08174
Location:902 → 1049

Anillin; Cell division protein anillin

pfam16018
Location:153 → 227

Anillin_N; Anillin N-terminus