U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Alp9 Alkaline phosphatase 9 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38633, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Alp9provided by FlyBase
    Official Full Name
    Alkaline phosphatase 9provided by FlyBase
    Primary source
    FLYBASE:FBgn0035620
    Locus tag
    Dmel_CG5150
    See related
    AllianceGenome:FB:FBgn0035620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5150; Dmel\CG5150
    Summary
    Predicted to enable alkaline phosphatase activity. Predicted to be located in cell surface. Is expressed in embryonic dorsal epidermis; embryonic/larval posterior spiracle; and embryonic/larval tracheal dorsal trunk. Human ortholog(s) of this gene implicated in inflammatory bowel disease. Orthologous to human ALPG (alkaline phosphatase, germ cell); ALPI (alkaline phosphatase, intestinal); and ALPP (alkaline phosphatase, placental). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Alp9 in Genome Data Viewer
    Location:
    64D5-64D5; 3-14 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5595542..5597422)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5588642..5590522)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene lethal (3) persistent salivary gland 2 Neighboring gene spook Neighboring gene Alkaline phosphatase 10 Neighboring gene uncharacterized protein Neighboring gene Transmembrane 9 superfamily protein member 3

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Intestinal alkaline phosphatase targets the gut barrier to prevent aging. Kühn F, et al. JCI Insight, 2020 Mar 26. PMID 32213701, Free PMC Article
    2. Activation of innate immunity during development induces unresolved dysbiotic inflammatory gut and shortens lifespan. Yamashita K, et al. Dis Model Mech, 2021 Sep 1. PMID 34448472, Free PMC Article
    3. Genome-wide analysis of phenobarbital-inducible genes in Drosophila melanogaster. Sun W, et al. Insect Mol Biol, 2006 Aug. PMID 16907832
    4. Genomic response to selection for postponed senescence in Drosophila. Wilson RH, et al. Mech Ageing Dev, 2013 Mar. PMID 23262286, Free PMC Article
    5. Endurance exercise and selective breeding for longevity extend Drosophila healthspan by overlapping mechanisms. Sujkowski A, et al. Aging (Albany NY), 2015 Aug. PMID 26298685, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alkaline phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alkaline phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    alkaline phosphatase 9
    Names
    Alp9-PA
    Alp9-PB
    CG5150-PA
    CG5150-PB
    NP_001286944.1
    NP_647977.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5595542..5597422
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300015.1 → NP_001286944.1  alkaline phosphatase 9, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286944.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRM9
      Conserved Domains (2) summary
      PRK10518
      Location:12 → 496
      PRK10518; alkaline phosphatase; Provisional
      cl23718
      Location:75 → 508
      ALP_like; alkaline phosphatases and sulfatases

    2. NM_139720.3 → NP_647977.1  alkaline phosphatase 9, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647977.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VRM9
      Related
      FBpp0076794
      Conserved Domains (2) summary
      PRK10518
      Location:12 → 496
      PRK10518; alkaline phosphatase; Provisional
      cl23718
      Location:75 → 508
      ALP_like; alkaline phosphatases and sulfatases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRM9 Q9VRM9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous