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    Sf3b2 Splicing factor 3b subunit 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33514, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sf3b2provided by FlyBase
    Official Full Name
    Splicing factor 3b subunit 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0031493
    Locus tag
    Dmel_CG3605
    See related
    AllianceGenome:FB:FBgn0031493
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3605; Dmel\CG3605; SF3B2
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including adult head; antennal primordium; embryonic/larval midgut primordium; head epidermis primordium; and mesoderm. Human ortholog(s) of this gene implicated in Goldenhar syndrome. Orthologous to human SF3B2 (splicing factor 3b subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Sf3b2 in Genome Data Viewer
    Location:
    23C4-23C4; 2-8 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (3026252..3029168, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (3026252..3029168, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene alpha1,4-galactosyltransferase 1 Neighboring gene pre-mRNA processing factor 40 Neighboring gene antisense RNA:CR44147 Neighboring gene uncharacterized protein Neighboring gene beta4GalNAcTB pilot Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Agaisse H, et al. Science, 2005 Aug 19. PMID 16020693
    2. Conserved functions of RNA-binding proteins in muscle. Nikonova E, et al. Int J Biochem Cell Biol, 2019 May. PMID 30818081
    3. The splicing co-factor Barricade/Tat-SF1 is required for cell cycle and lineage progression in Drosophila neural stem cells. Abramczuk MK, et al. Development, 2017 Nov 1. PMID 28935704
    4. The Exon Junction Complex and Srp54 Contribute to Hedgehog Signaling via ci RNA Splicing in Drosophila melanogaster. Garcia-Garcia E, et al. Genetics, 2017 Aug. PMID 28637711, Free PMC Article
    5. Computational identification of Ftz/Ftz-F1 downstream target genes. Bowler T, et al. Dev Biol, 2006 Nov 1. PMID 16996052

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U12-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2 snRNP ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of U2-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome HDA PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    splicing factor 3b subunit 2
    Names
    CG3605-PA
    CG3605-PB
    Sf3b2-PA
    Sf3b2-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      3026252..3029168 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273050.1 → NP_001259979.1  splicing factor 3b subunit 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259979.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RC1, Q9VQK7
      Conserved Domains (3) summary
      smart00581
      Location:451 → 508
      PSP; proline-rich domain in spliceosome associated proteins
      COG5182
      Location:166 → 536
      CUS1; Splicing factor 3b, subunit 2 [RNA processing and modification]
      pfam04037
      Location:320 → 446
      DUF382; Domain of unknown function (DUF382)

    2. NM_134895.4 → NP_608739.1  splicing factor 3b subunit 2, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608739.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95RC1, Q9VQK7
      Related
      FBpp0077353
      Conserved Domains (3) summary
      smart00581
      Location:451 → 508
      PSP; proline-rich domain in spliceosome associated proteins
      COG5182
      Location:166 → 536
      CUS1; Splicing factor 3b, subunit 2 [RNA processing and modification]
      pfam04037
      Location:320 → 446
      DUF382; Domain of unknown function (DUF382)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VQK7 Q9VQK7

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