hppy happyhour [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: hppyprovided by FlyBase
Official Full Name: happyhourprovided by FlyBase
Primary source: FLYBASE:FBgn0263395
Locus tag: Dmel_CG7097
See related: AllianceGenome:FB:FBgn0263395
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0153538.68; CG7097; CG7097/hppy; Dmel\CG7097; EP-704; GLK/KHS1; Hppy; l(2)SH1261; l(2)SH2 1261; MAP4K3
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including behavioral response to ethanol; positive regulation of cell size; and positive regulation of intracellular signal transduction. Located in cytosol. Is expressed in adult head; organism; pole plasm; and wing disc. Used to study alcohol use disorder. Orthologous to several human genes including MAP4K5 (mitogen-activated protein kinase kinase kinase kinase 5). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 56C1-56C4; 2-88 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (19178738..19227193)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (15066243..15114698)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

hppy expression triggers the activation of both the c-Jun N-terminal kinase (JNK) and target of rapamycin (TOR) signalling pathways.
Title: Drosophila happyhour modulates JNK-dependent apoptosis.
MAP4K3 has two independent functions during wing development, one related to activation of the JNK pathway in response to stress and other in assembling or activation of the TORC1 complex, modulating cellular responses to changes in nutrient availability.
Title: MAP4K3 is a component of the TORC1 signalling complex that modulates cell growth and viability in Drosophila melanogaster.
MAP4K3 regulates body size and metabolism in Drosophila
Title: MAP4K3 regulates body size and metabolism in Drosophila.
Genetic and biochemical experiments revealed that the epidermal growth factor (EGF)-signaling pathway regulates ethanol sensitivity in Drosophila and that happy hour (hppy, CG7097) functions as an inhibitor of the pathway.
Title: Happyhour, a Ste20 family kinase, implicates EGFR signaling in ethanol-induced behaviors.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase kinase kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of epidermal growth factor receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TOR signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of TORC1 signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hippo signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell size	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of growth rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: happyhour

Names: CG7097-PA; CG7097-PB; CG7097-PC; CG7097-PD; CG7097-PE; gene 2; happy hour; hppy-PA; hppy-PB; hppy-PC; hppy-PD; hppy-PE; lethal (2) SH1261

NP_001286604.1

EC 2.7.11.1

NP_001286605.1

EC 2.7.11.1

NP_001286606.1

EC 2.7.11.1

NP_611399.2

EC 2.7.11.1

NP_725863.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

19178738..19227193

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299675.1 → NP_001286604.1 happyhour, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286604.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LGY8, Q8SYA1

Conserved Domains (3) summary

smart00220
Location:26 → 283

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06613
Location:25 → 283

STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

pfam00780
Location:619 → 934

CNH; CNH domain
NM_166335.3 → NP_725863.1 happyhour, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725863.1

Status: REVIEWED

UniProtKB/TrEMBL

A1ZBH7

Related

FBpp0085692

Conserved Domains (3) summary

smart00220
Location:26 → 283

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06613
Location:25 → 283

STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

pfam00780
Location:869 → 1184

CNH; CNH domain
NM_137555.3 → NP_611399.2 happyhour, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611399.2

Status: REVIEWED

UniProtKB/TrEMBL

A1ZBH8, Q8SYA1

Related

FBpp0085691

Conserved Domains (3) summary

smart00220
Location:26 → 283

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06613
Location:25 → 283

STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

pfam00780
Location:598 → 913

CNH; CNH domain
NM_001299676.1 → NP_001286605.1 happyhour, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286605.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LFV0

Conserved Domains (3) summary

smart00220
Location:26 → 283

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06613
Location:25 → 283

STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

pfam00780
Location:856 → 1171

CNH; CNH domain
NM_001299677.1 → NP_001286606.1 happyhour, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286606.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LFQ3, Q8SYA1

Conserved Domains (3) summary

smart00220
Location:26 → 283

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd06613
Location:25 → 283

STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

pfam00780
Location:585 → 900

CNH; CNH domain