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    Nsun5 Nop2/Sun-like domain containing protein 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 7354421, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Nsun5provided by FlyBase
    Official Full Name
    Nop2/Sun-like domain containing protein 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0259704
    Locus tag
    Dmel_CG42358
    See related
    AllianceGenome:FB:FBgn0259704
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG42358; CG5558; Dmel\CG42358; dNsun5
    Old locus tag
    Dmel_CG5558
    Summary
    Predicted to enable rRNA (cytosine-C5-)-methyltransferase activity. Involved in defense response to Gram-negative bacterium and positive regulation of innate immune response. Predicted to be active in nucleolus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; dorsal pharyngeal muscle cell; embryonic/larval midgut primordium; and gut section. Orthologous to several human genes including NSUN5 (NOP2/Sun RNA methyltransferase 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Nsun5 in Genome Data Viewer
    Location:
    91F4-91F4; 3-66 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19160099..19162300, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14985821..14988022, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44107 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene nanos Neighboring gene uncharacterized protein Neighboring gene squeeze Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan. Schosserer M, et al. Nat Commun, 2015 Jan 30. PMID 25635753, Free PMC Article
    2. A Fat-Facets-Dscam1-JNK Pathway Enhances Axonal Growth in Development and after Injury. Koch M, et al. Front Cell Neurosci, 2017. PMID 29472843, Free PMC Article
    3. H/ACA snRNP-dependent ribosome biogenesis regulates translation of polyglutamine proteins. Breznak SM, et al. Sci Adv, 2023 Jun 23. PMID 37343092, Free PMC Article
    4. Drosophila models of pathogenic copy-number variant genes show global and non-neuronal defects during development. Yusuff T, et al. PLoS Genet, 2020 Jun. PMID 32579612, Free PMC Article
    5. Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection. Cronin SJ, et al. Science, 2009 Jul 17. PMID 19520911, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (cytosine-C5-)-methyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to Gram-negative bacterium HMP PubMed 
    involved_in positive regulation of innate immune response HMP PubMed 
    involved_in rRNA base methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Nop2/Sun-like domain containing protein 5
    Names
    CG42358-PA
    Nsun5-PA
    NP_650787.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19160099..19162300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142530.3 → NP_650787.1  Nop2/Sun-like domain containing protein 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650787.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VDZ4
      Conserved Domains (1) summary
      COG0144
      Location:124 → 428
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDZ4.1 Q9VDZ4

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