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    BMP7 bone morphogenetic protein 7 [ Homo sapiens (human) ]

    Gene ID: 655, updated on 4-Jan-2025

    Summary

    Official Symbol
    BMP7provided by HGNC
    Official Full Name
    bone morphogenetic protein 7provided by HGNC
    Primary source
    HGNC:HGNC:1074
    See related
    Ensembl:ENSG00000101144 MIM:112267; AllianceGenome:HGNC:1074
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OP-1
    Summary
    This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer, which plays a role in bone, kidney and brown adipose tissue development. Additionally, this protein induces ectopic bone formation and may promote fracture healing in human patients. [provided by RefSeq, Jul 2016]
    Expression
    Biased expression in thyroid (RPKM 30.0), placenta (RPKM 15.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See BMP7 in Genome Data Viewer
    Location:
    20q13.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (57168753..57266641, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (58946552..59044382, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (55743809..55841697, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372685 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55707263-55707764 Neighboring gene VISTA enhancer hs2565 Neighboring gene uncharacterized LOC105372686 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55736368-55736868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55747859-55748360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55758285-55758807 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55758808-55759329 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:55773380-55774038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:55774039-55774698 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr20:55780300-55781499 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55798567-55799068 Neighboring gene BMP7 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55801141-55801641 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:55806824-55807357 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:55807358-55807890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55819232-55820156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55834429-55834991 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55837926-55838642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55839361-55840076 Neighboring gene BMP7 promoter region Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC105372687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55861989-55862490 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55862491-55862990 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55865617-55866584 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55867403-55867902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55876343-55876878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:55892097-55892598 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr20:55901391-55901894 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr20:55901895-55902397 Neighboring gene microRNA 4325 Neighboring gene ribosomal protein L39 pseudogene 39

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (16 hits/1358 screens)

    EBI GWAS Catalog

    Description
    A genomewide association study of citalopram response in major depressive disorder.
    EBI GWAS Catalog
    Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 reduces osteoblast function and significantly decreases the levels of BMP-7 and RANK-L PubMed
    Pr55(Gag) gag HIV-1 Gag reduces osteoblast function and significantly reduces the levels of BMP-2, BMP-7, osteocalcin, and RANK-L PubMed
    Tat tat Treatment of pulmonary arterial smooth muscle cells with HIV-1 Tat induces significantly higher secretion of BMP-2 and BMP-7 ligands when compared with that of untreated cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables BMP receptor binding PubMed 
    enables cytokine activity  
    enables growth factor activity PubMed 
    enables heparin binding  
    enables protein binding PubMed 
    enables protein serine/threonine kinase activator activity PubMed 
    Items 1 - 25 of 76
    Process Evidence Code Pubs
    involved_in BMP signaling pathway  
    involved_in BMP signaling pathway PubMed 
    involved_in BMP signaling pathway PubMed 
    involved_in BMP signaling pathway PubMed 
    involved_in allantois development  
    involved_in ameloblast differentiation  
    involved_in axon guidance  
    involved_in branching involved in salivary gland morphogenesis  
    involved_in branching morphogenesis of an epithelial tube  
    involved_in cardiac muscle tissue development  
    involved_in cardiac septum morphogenesis  
    involved_in cartilage development  
    involved_in cellular response to BMP stimulus PubMed 
    involved_in cellular response to hypoxia  
    involved_in chorio-allantoic fusion  
    involved_in dendrite development PubMed 
    involved_in embryonic camera-type eye morphogenesis  
    involved_in embryonic limb morphogenesis  
    involved_in embryonic pattern specification  
    involved_in embryonic skeletal joint morphogenesis  
    involved_in endocardial cushion formation  
    involved_in epithelial to mesenchymal transition PubMed 
    involved_in heart trabecula morphogenesis  
    involved_in hindbrain development  
    involved_in mesenchymal cell apoptotic process involved in nephron morphogenesis  
    involved_in mesenchymal cell differentiation PubMed 
    involved_in mesenchyme development  
    involved_in mesoderm formation  
    involved_in mesonephros development PubMed 
    involved_in metanephric mesenchymal cell proliferation involved in metanephros development  
    involved_in metanephric mesenchyme morphogenesis  
    involved_in metanephros development PubMed 
    involved_in monocyte aggregation PubMed 
    involved_in negative regulation of DNA-templated transcription PubMed 
    involved_in negative regulation of NF-kappaB transcription factor activity  
    involved_in negative regulation of Notch signaling pathway  
    involved_in negative regulation of cell cycle PubMed 
    involved_in negative regulation of glomerular mesangial cell proliferation PubMed 
    involved_in negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis  
    involved_in negative regulation of mitotic nuclear division PubMed 
    involved_in negative regulation of neurogenesis  
    acts_upstream_of_or_within negative regulation of neuron differentiation PubMed 
    involved_in negative regulation of non-canonical NF-kappaB signal transduction  
    involved_in negative regulation of prostatic bud formation  
    involved_in negative regulation of striated muscle cell apoptotic process  
    involved_in nephrogenic mesenchyme morphogenesis  
    involved_in neural fold elevation formation  
    acts_upstream_of_or_within neuron projection morphogenesis PubMed 
    involved_in odontogenesis of dentin-containing tooth  
    involved_in osteoblast differentiation PubMed 
    involved_in pericardium morphogenesis  
    involved_in pharyngeal system development  
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of SMAD protein signal transduction PubMed 
    involved_in positive regulation of SMAD protein signal transduction PubMed 
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of bone mineralization PubMed 
    involved_in positive regulation of brown fat cell differentiation PubMed 
    involved_in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis  
    involved_in positive regulation of dendrite development PubMed 
    involved_in positive regulation of epithelial cell differentiation  
    involved_in positive regulation of epithelial to mesenchymal transition  
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of heterotypic cell-cell adhesion PubMed 
    involved_in positive regulation of hyaluranon cable assembly PubMed 
    involved_in positive regulation of neuron differentiation  
    involved_in positive regulation of osteoblast differentiation PubMed 
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in regulation of branching involved in prostate gland morphogenesis  
    involved_in regulation of removal of superoxide radicals  
    involved_in response to estradiol  
    involved_in response to peptide hormone  
    involved_in response to vitamin D  
    involved_in skeletal system development PubMed 
    involved_in ureteric bud development  
    Items 1 - 25 of 76
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix  
    located_in extracellular region  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in vesicle  

    General protein information

    Preferred Names
    bone morphogenetic protein 7
    Names
    osteogenic protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032771.1 RefSeqGene

      Range
      5011..102899
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001719.3 → NP_001710.1  bone morphogenetic protein 7 preproprotein

      See identical proteins and their annotated locations for NP_001710.1

      Status: REVIEWED

      Source sequence(s)
      AK291186, AL157414, BM683430, DA740733
      Consensus CDS
      CCDS13455.1
      UniProtKB/Swiss-Prot
      P18075, Q9H512, Q9NTQ7
      UniProtKB/TrEMBL
      A8K571, B2ZPJ8
      Related
      ENSP00000379204.3, ENST00000395863.8
      Conserved Domains (2) summary
      pfam00688
      Location:35 → 280
      TGFb_propeptide; TGF-beta propeptide
      cd19397
      Location:325 → 431
      TGF_beta_BMP7; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      57168753..57266641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      58946552..59044382 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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