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    Ptprq protein tyrosine phosphatase, receptor type, Q [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360417, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ptprqprovided by RGD
    Official Full Name
    protein tyrosine phosphatase, receptor type, Qprovided by RGD
    Primary source
    RGD:620779
    See related
    EnsemblRapid:ENSRNOG00000056915 AllianceGenome:RGD:620779
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    rPTP-GMC1
    Summary
    Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in detection of mechanical stimulus involved in sensory perception of sound and regulation of fat cell differentiation. Predicted to act upstream of or within hematopoietic progenitor cell differentiation; neuromuscular process controlling balance; and vestibular receptor cell morphogenesis. Predicted to be located in apical plasma membrane and stereocilium base. Predicted to be part of receptor complex. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 73 and autosomal recessive nonsyndromic deafness 84A. Orthologous to human PTPRQ (protein tyrosine phosphatase receptor type Q). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 9.9), Kidney (RPKM 2.7) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptprq in Genome Data Viewer
    Location:
    7q21
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (44720916..44903291, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (42834455..43016807, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (49763657..50034932, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093580 Neighboring gene myogenic factor 5 Neighboring gene myogenic factor 6 Neighboring gene otogelin-like Neighboring gene protein phosphatase 1, regulatory subunit 12A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Involvement of PTP-RQ in differentiation during adipogenesis of human mesenchymal stem cells. Jung H, et al. Biochem Biophys Res Commun, 2009 May 29. PMID 19351528
    2. PTPRQ is a novel phosphatidylinositol phosphatase that can be expressed as a cytoplasmic protein or as a subcellularly localized receptor-like protein. Seifert RA, et al. Exp Cell Res, 2003 Jul 15. PMID 12837292
    3. Hair bundle defects and loss of function in the vestibular end organs of mice lacking the receptor-like inositol lipid phosphatase PTPRQ. Goodyear RJ, et al. J Neurosci, 2012 Feb 22. PMID 22357859, Free PMC Article
    4. A receptor-like inositol lipid phosphatase is required for the maturation of developing cochlear hair bundles. Goodyear RJ, et al. J Neurosci, 2003 Oct 8. PMID 14534255, Free PMC Article
    5. Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation. Oganesian A, et al. Proc Natl Acad Sci U S A, 2003 Jun 24. PMID 12802008, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PTPRQ represents a subtype of the PTPases whose biological activities result from its PIPase activity rather than its PTPase activity
      Title: Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of mechanical stimulus involved in sensory perception of sound IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of mechanical stimulus involved in sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within detection of mechanical stimulus involved in sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in hematopoietic progenitor cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inner ear morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neuromuscular process controlling balance IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neuromuscular process controlling balance ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in vestibular receptor cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within vestibular receptor cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in basal plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in stereocilium base IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in stereocilium base ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stereocilium base ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in stereocilium bundle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphatidylinositol phosphatase PTPRQ
    Names
    PTP-RQ
    R-PTP-Q
    glomerular mesangial cell receptor protein-tyrosine phosphatase
    phosphotidylinositol phosphatase PTPRQ
    protein-tyrosine phosphatase receptor-type expressed by glomerular mesangial cells protein 1
    receptor-type tyrosine-protein phosphatase Q
    NP_075214.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022925.2 → NP_075214.2  phosphatidylinositol phosphatase PTPRQ precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/Swiss-Prot
      O88488
      UniProtKB/TrEMBL
      A0A0G2JUZ7, A6IGD1
      Related
      ENSRNOP00000069293.2, ENSRNOT00000081885.3
      Conserved Domains (5) summary
      cd00063
      Location:58 → 152
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl06408
      Location:1760 → 1929
      UP_III_II; Uroplakin IIIb, IIIa and II
      cd14616
      Location:2034 → 2257
      R-PTPc-Q; catalytic domain of receptor-type tyrosine-protein phosphatase Q
      pfam00041
      Location:669 → 748
      fn3; Fibronectin type III domain
      cl21522
      Location:400 → 442
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      44720916..44903291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198323.1: Suppressed sequence

      Description
      NM_198323.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88488.1 GenPept UniProtKB/Swiss-Prot:O88488

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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