Pigr polymeric immunoglobulin receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pigrprovided by RGD
Official Full Name: polymeric immunoglobulin receptorprovided by RGD
Primary source: RGD:3328
See related: EnsemblRapid:ENSRNOG00000004405 AllianceGenome:RGD:3328
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: pIgA-R; RNPIGR2
Summary: Enables epidermal growth factor receptor binding activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; detection of chemical stimulus involved in sensory perception of bitter taste; and immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor. Located in recycling endosome membrane. Orthologous to human PIGR (polymeric immunoglobulin receptor). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Liver (RPKM 1995.5), Lung (RPKM 458.8) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (44851001..44879143)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (42298905..42326877)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (47564176..47592093)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Salivary Immunoglobulin A Secretion and Polymeric Ig Receptor Expression in the Submandibular Glands Are Enhanced in Heat-Acclimated Rats.
Title: Salivary Immunoglobulin A Secretion and Polymeric Ig Receptor Expression in the Submandibular Glands Are Enhanced in Heat-Acclimated Rats.
Results reveal a novel Yes-EGFR-ERK-FIP5 signalling network for regulation of pIgA-pIgR transcytosis.
Title: A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor.
Data show that in addition to its role in transcytosis, MAL2 also regulates polymeric IgA receptor delivery from the Golgi to the plasma membrane.
Title: MAL2 selectively regulates polymeric IgA receptor delivery from the Golgi to the plasma membrane in WIF-B cells.
pIgA-R traffics through postendosomal rab3D-, rab11a-, and syntaxin 2-associated compartments, implicating these proteins in the regulation of transcytosis
Title: Intracellular accumulation of pIgA-R and regulators of transcytotic trafficking in cholestatic rat hepatocytes.

Submit: New GeneRIF Correction

General gene information

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Markers

BM382949 (e-PCR)
- UniSTS:260971

RH132169 (e-PCR)
- UniSTS:215452

D13Wox15 (e-PCR)
- UniSTS:517813

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables epidermal growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables polymeric immunoglobulin binding	IEA Inferred from Electronic Annotation more info
enables polymeric immunoglobulin binding	ISO Inferred from Sequence Orthology more info
enables polymeric immunoglobulin receptor activity	IEA Inferred from Electronic Annotation more info
enables polymeric immunoglobulin receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Fc receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Fc receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IEA Inferred from Electronic Annotation more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor	IBA Inferred from Biological aspect of Ancestor more info
involved_in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor	IEA Inferred from Electronic Annotation more info
involved_in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor	ISO Inferred from Sequence Orthology more info
involved_in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor clustering	IEA Inferred from Electronic Annotation more info
involved_in receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	IDA Inferred from Direct Assay more info	PubMed
part_of secretory IgA immunoglobulin complex	IEA Inferred from Electronic Annotation more info
part_of secretory IgA immunoglobulin complex	ISO Inferred from Sequence Orthology more info
part_of secretory IgA immunoglobulin complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: polymeric immunoglobulin receptor

Names: poly-Ig receptor; polymeric IgA receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429542.1 → NP_001416471.1 polymeric immunoglobulin receptor precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P15083
NM_001429543.1 → NP_001416472.1 polymeric immunoglobulin receptor precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P15083
NM_012723.5 → NP_036855.3 polymeric immunoglobulin receptor precursor

See identical proteins and their annotated locations for NP_036855.3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

P15083

UniProtKB/TrEMBL

F1M7H2

Conserved Domains (2) summary

cd05716
Location:357 → 456

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:469 → 558

IG_like; Immunoglobulin like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

44851001..44879143

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090372.2 → XP_038946300.1 polymeric immunoglobulin receptor isoform X1

Conserved Domains (3) summary

cd00096
Location:144 → 146

Ig; Ig strand A [structural motif]

cd05716
Location:477 → 572

IgV_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins

cl11960
Location:144 → 237

Ig; Immunoglobulin domain
XM_039090371.2 → XP_038946299.1 polymeric immunoglobulin receptor isoform X1

Related

ENSRNOP00000073562.2, ENSRNOT00000088449.3

Conserved Domains (3) summary

cd00096
Location:144 → 146

Ig; Ig strand A [structural motif]

cd05716
Location:477 → 572

IgV_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins

cl11960
Location:144 → 237

Ig; Immunoglobulin domain
XM_063272039.1 → XP_063128109.1 polymeric immunoglobulin receptor isoform X1

UniProtKB/TrEMBL

A0A0G2K5U5