St3gal2 ST3 beta-galactoside alpha-2,3-sialyltransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: St3gal2provided by RGD
Official Full Name: ST3 beta-galactoside alpha-2,3-sialyltransferase 2provided by RGD
Primary source: RGD:68413
See related: EnsemblRapid:ENSRNOG00000017932 AllianceGenome:RGD:68413
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Siat5; Siat4b
Summary: Enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity. Involved in ganglioside biosynthetic process via lactosylceramide. Predicted to be located in Golgi membrane. Predicted to be active in membrane. Orthologous to human ST3GAL2 (ST3 beta-galactoside alpha-2,3-sialyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 149.0), Muscle (RPKM 140.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (55798112..55849226)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (38888851..38939874)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (43273251..43324265, complement)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Use of sialyl mucin core 2 compounds shows how ST3Gal-II exchanges sialyl residues between CMP-NeuAc and the NeuAcalpha2,3Galbeta1,3GalNAc unit, while also radiolabeling sialyl residues in gangliosides GD1a and GT1b, but not GM1.
Title: Mammalian sialyltransferase ST3Gal-II: its exchange sialylation catalytic properties allow labeling of sialyl residues in mucin-type sialylated glycoproteins and specific gangliosides.

Submit: New GeneRIF Correction

General gene information

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Markers

RH139813 (e-PCR)
- UniSTS:221897

BF387076 (e-PCR)
- UniSTS:244179

RH140953 (e-PCR)
- UniSTS:222954

AA850466 (e-PCR)
- UniSTS:250356

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase	IEA Inferred from Electronic Annotation more info
enables beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase	ISO Inferred from Sequence Orthology more info
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	IEA Inferred from Electronic Annotation more info
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables sialyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ganglioside biosynthetic process via lactosylceramide	IBA Inferred from Biological aspect of Ancestor more info
involved_in ganglioside biosynthetic process via lactosylceramide	IDA Inferred from Direct Assay more info	PubMed
involved_in ganglioside biosynthetic process via lactosylceramide	IEA Inferred from Electronic Annotation more info
involved_in ganglioside biosynthetic process via lactosylceramide	ISO Inferred from Sequence Orthology more info
involved_in globoside biosynthetic process via lactosylceramide	IEA Inferred from Electronic Annotation more info
involved_in globoside biosynthetic process via lactosylceramide	ISO Inferred from Sequence Orthology more info
involved_in globoside biosynthetic process via lactosylceramide	ISS Inferred from Sequence or Structural Similarity more info
involved_in glycolipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in glycoprotein biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in lipid glycosylation	IEA Inferred from Electronic Annotation more info
involved_in lipid glycosylation	ISO Inferred from Sequence Orthology more info
involved_in oligosaccharide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in oligosaccharide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein glycosylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein glycosylation	ISO Inferred from Sequence Orthology more info
involved_in protein sialylation	ISO Inferred from Sequence Orthology more info
involved_in sialylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in sialylation	IEA Inferred from Electronic Annotation more info
involved_in sialylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi cisterna membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

Names: SIAT4-B; ST3GALA.2; ST3Gal II; ST3GalII; alpha 2,3-ST 2; beta-galactoside alpha-2,3-sialyltransferase 2; gal-NAc6S; gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase; monosialoganglioside sialyltransferase; sialyltransferase 4B (beta-galactoside alpha-2,3-sialyltransferase); sialyltransferase 5

NP_113883.2

EC 2.4.3.2

EC 2.4.3.4

XP_006255687.1

EC 2.4.3.2

EC 2.4.3.4

XP_006255688.1

EC 2.4.3.2

EC 2.4.3.4

XP_006255689.1

EC 2.4.3.2

EC 2.4.3.4

XP_038953889.1

EC 2.4.3.2

EC 2.4.3.4

XP_038953890.1

EC 2.4.3.2

EC 2.4.3.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031695.2 → NP_113883.2 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2

See identical proteins and their annotated locations for NP_113883.2

Status: VALIDATED

Source sequence(s)

CO404237, EV769154, JAXUCZ010000019, X76988

UniProtKB/Swiss-Prot

Q11205

UniProtKB/TrEMBL

A6IZ75, G3V8B2

Conserved Domains (1) summary

pfam00777
Location:94 → 348

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086037.1 Reference GRCr8

Range

55798112..55849226

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039097961.2 → XP_038953889.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 isoform X1

UniProtKB/Swiss-Prot

Q11205

UniProtKB/TrEMBL

A6IZ75, G3V8B2

Conserved Domains (1) summary

pfam00777
Location:94 → 348

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
XM_006255627.5 → XP_006255689.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 isoform X1

See identical proteins and their annotated locations for XP_006255689.1

UniProtKB/Swiss-Prot

Q11205

UniProtKB/TrEMBL

A6IZ75, G3V8B2

Conserved Domains (1) summary

pfam00777
Location:94 → 348

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
XM_006255625.5 → XP_006255687.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 isoform X1

See identical proteins and their annotated locations for XP_006255687.1

UniProtKB/Swiss-Prot

Q11205

UniProtKB/TrEMBL

A6IZ75, G3V8B2

Related

ENSRNOP00000024248.2, ENSRNOT00000024248.5

Conserved Domains (1) summary

pfam00777
Location:94 → 348

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
XM_006255626.5 → XP_006255688.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 isoform X1

See identical proteins and their annotated locations for XP_006255688.1

UniProtKB/Swiss-Prot

Q11205

UniProtKB/TrEMBL

A6IZ75, G3V8B2

Conserved Domains (1) summary

pfam00777
Location:94 → 348

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
XM_039097962.2 → XP_038953890.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 2 isoform X2

Conserved Domains (1) summary

pfam00777
Location:11 → 237

Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)