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    Krt10 keratin 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 450225, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Krt10provided by RGD
    Official Full Name
    keratin 10provided by RGD
    Primary source
    RGD:1359092
    See related
    EnsemblRapid:ENSRNOG00000030170 AllianceGenome:RGD:1359092
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ka10
    Summary
    Predicted to enable cytoskeletal protein binding activity and protein heterodimerization activity. Predicted to be a structural constituent of skin epidermis. Predicted to be involved in several processes, including intermediate filament organization; peptide cross-linking; and protein heterotetramerization. Predicted to act upstream of or within cellular response to calcium ion; keratinocyte development; and stem cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in cornified envelope and keratin filament. Human ortholog(s) of this gene implicated in epidermolytic hyperkeratosis and epidermolytic hyperkeratosis 2. Orthologous to human KRT10 (keratin 10). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Adrenal (RPKM 17.3), Kidney (RPKM 14.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Krt10 in Genome Data Viewer
    Location:
    10q31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (84834865..84839160, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (84338695..84343279, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (87296445..87301307, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene keratin 27 Neighboring gene uncharacterized LOC108352132 Neighboring gene keratin 28 Neighboring gene uncharacterized LOC134480872 Neighboring gene keratin 12 Neighboring gene keratin 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity. Syder AJ, et al. J Clin Invest, 1994 Apr. PMID 7512983, Free PMC Article
    2. Keratins K2 and K10 are essential for the epidermal integrity of plantar skin. Fischer H, et al. J Dermatol Sci, 2016 Jan. PMID 26603179
    3. The X-Ray Crystal Structure of the Keratin 1-Keratin 10 Helix 2B Heterodimer Reveals Molecular Surface Properties and Biochemical Insights into Human Skin Disease. Bunick CG, et al. J Invest Dermatol, 2017 Jan. PMID 27595935, Free PMC Article
    4. Loss of keratin K2 expression causes aberrant aggregation of K10, hyperkeratosis, and inflammation. Fischer H, et al. J Invest Dermatol, 2014 Oct. PMID 24751727
    5. Aldo-keto reductase 1C3 is expressed in differentiated human epidermis, affects keratinocyte differentiation, and is upregulated in atopic dermatitis. Mantel A, et al. J Invest Dermatol, 2012 Apr. PMID 22170488, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of skin epidermis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of skin epidermis IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of skin epidermis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epidermis development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within epidermis development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intermediate filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within intermediate filament organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within keratinocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in keratinocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptide cross-linking ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epidermis development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epidermis development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein heterotetramerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein heterotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein heterotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within stem cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cornified envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cornified envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cornified envelope ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in keratin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in keratin filament IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in keratin filament ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    keratin, type I cytoskeletal 10
    Names
    CK-10
    K10
    cytokeratin-10
    keratin 10, type I
    type I keratin KA10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001413356.1 → NP_001400285.1  keratin, type I cytoskeletal 10

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      84834865..84839160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269571.1 → XP_063125641.1  keratin, type I cytoskeletal 10 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2V6
      Related
      ENSRNOP00000072394.1, ENSRNOT00000081709.3

    2. XM_063269572.1 → XP_063125642.1  keratin, type I cytoskeletal 10 isoform X2

      UniProtKB/Swiss-Prot
      Q6IFW6
      Related
      ENSRNOP00000029821.2, ENSRNOT00000036023.5

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001008804.1: Suppressed sequence

      Description
      NM_001008804.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6IFW6.1 GenPept UniProtKB/Swiss-Prot:Q6IFW6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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