SHS1 septin SHS1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SHS1
Official Full Name: septin SHS1
Primary source: SGD:S000002384
Locus tag: YDL225W
See related: AllianceGenome:SGD:S000002384; FungiDB:YDL225W; VEuPathDB:YDL225W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SEP7
Summary: Enables GTP binding activity. A structural constituent of cytoskeleton. Involved in several processes, including cytokinetic process; endoplasmic reticulum polarization; and mitotic cell cycle phase transition. Located in cellular bud neck septin ring. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to several human genes including SEPTIN10 (septin 10); SEPTIN11 (septin 11); and SEPTIN14 (septin 14). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SHS1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (52445..54100)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interplay of septin amphipathic helices in sensing membrane-curvature and filament bundling.
Title: Interplay of septin amphipathic helices in sensing membrane-curvature and filament bundling.
Reconstructed evolutionary history of the yeast septins Cdc11 and Shs1.
Title: Reconstructed evolutionary history of the yeast septins Cdc11 and Shs1.
Synergistic role of nucleotides and lipids for the self-assembly of Shs1 septin oligomers.
Title: Synergistic role of nucleotides and lipids for the self-assembly of Shs1 septin oligomers.
The relative proportion of Cdc11/Shs1 septin complexes controls the biophysical properties of filaments and influences the rate of annealing, fragmentation, and filament flexibility. An Shs1 mutant that is predicted to alter nucleotide hydrolysis has altered filament length and dynamics in cells and impacts cell morphogenesis.
Title: Control of septin filament flexibility and bundling by subunit composition and nucleotide interactions.
Important function of the CTEs of Cdc11 and Shs1 is optimizing recruitment of Bni5 and thereby ensuring efficient localization at the bud neck of Myo1, the type II myosin of the actomyosin contractile ring.
Title: The Carboxy-Terminal Tails of Septins Cdc11 and Shs1 Recruit Myosin-II Binding Factor Bni5 to the Bud Neck in Saccharomyces cerevisiae.
The sole portion of Shs1 essential for its function is predicted coiled-coil-forming segment in its C-terminal extension (CTE). CTE of Cdc11 shares this function. This role for the CTEs of Cdc11 and Shs1 is distinct from that of the CTEs of Cdc3 and Cdc12
Title: Comprehensive Genetic Analysis of Paralogous Terminal Septin Subunits Shs1 and Cdc11 in Saccharomyces cerevisiae.
Study shows that a direct interaction between the endoplasmic reticulum (ER) protein Scs2 and the septin Shs1 creates the diffusion barrier in yeast. Barrier formation requires Epo1, a novel ER-associated subunit of the polarisome that interacts with Scs2 and Shs1, encoded by the ORF YMR124W.
Title: Polarization of the endoplasmic reticulum by ER-septin tethering.
It was shown that Shs1 substitutes for Cdc11, resulting in octameric rods that do not polymerize into filaments but associate laterally, forming curved bundles that close into rings.
Title: Subunit-dependent modulation of septin assembly: budding yeast septin Shs1 promotes ring and gauze formation.
Septin Shs1 appears to have an important role in the response to DNA replication stress.
Title: An FHA domain-mediated protein interaction network of Rad53 reveals its role in polarized cell growth.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in actomyosin contractile ring assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular bud neck septin ring organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular bud neck septin ring organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cytoskeleton-dependent cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in division septum assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in division septum assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum polarization	IDA Inferred from Direct Assay more info	PubMed
involved_in exit from mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic actomyosin contractile ring assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to bud neck	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to bud neck	IGI Inferred from Genetic Interaction more info	PubMed
involved_in septin ring assembly	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell division site	IBA Inferred from Biological aspect of Ancestor more info
located_in cellular bud neck	HDA more info	PubMed
located_in cellular bud neck	IEA Inferred from Electronic Annotation more info
located_in cellular bud neck	IPI Inferred from Physical Interaction more info	PubMed
located_in cellular bud neck septin ring	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mating projection tip	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in prospore membrane	HDA more info	PubMed
part_of septin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of septin complex	IEA Inferred from Electronic Annotation more info
is_active_in septin ring	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: septin SHS1

NP_010056.1

Component of the septin ring that is required for cytokinesis; present at the ends of rod-like septin hetero-oligomers; C-terminal extension is important for recruitment of Bni5p to the mother-bud neck, which in turn is required for Myo1p recruitment and cytokinesis; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

52445..54100

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180285.1 → NP_010056.1 TPA: septin SHS1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010056.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRD0, Q07657

UniProtKB/TrEMBL

C7GSV3, N1P4A6

Conserved Domains (1) summary

COG5019
Location:1 → 519

CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]