Atp2b4 ATPase plasma membrane Ca2+ transporting 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Atp2b4provided by RGD
Full Name: ATPase plasma membrane Ca2+ transporting 4provided by RGD
Primary source: RGD:621305
See related: EnsemblRapid:ENSRNOG00000003031 AllianceGenome:RGD:621305
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PMCA4
Summary: Enables P-type calcium transporter activity; PDZ domain binding activity; and protein kinase binding activity. Involved in several processes, including calcium ion transport; hippocampus development; and negative regulation of calcineurin-NFAT signaling cascade. Located in basolateral plasma membrane and sperm principal piece. Is active in glutamatergic synapse and presynaptic active zone membrane. Biomarker of dystonia. Orthologous to human ATP2B4 (ATPase plasma membrane Ca2+ transporting 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Uterus (RPKM 146.2), Lung (RPKM 129.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q13

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (47708157..47807389, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (45156137..45255292, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (50091644..50153808)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mammalian cysteine-rich secretory proteins interact with plasma membrane Ca[2+] exporter PMCA4b.
Title: Mammalian cysteine-rich secretory proteins interact with plasma membrane Ca(2+) exporter PMCA4b.
This result indicates that the interaction of PMCA4 with calcineurin A plays a regulatory role in the signalling during catecholamine secretion.
Title: Interaction of plasma membrane Ca(2+)-ATPase isoform 4 with calcineurin A: implications for catecholamine secretion by PC12 cells.
The plasma membrane Ca(2+)-ATPase is a sensitive target of oxidative stress in primary neurons. Inactivation of this Ca(2+) transporter under prolonged oxidative stress could alter neuronal Ca(2+) signaling.
Title: Effects of paraquat-induced oxidative stress on the neuronal plasma membrane Ca(2+)-ATPase.
the nNOS-PMCA4b complex regulates contractility via cAMP and phosphorylation of both PLB and cTnI.
Title: Specific role of neuronal nitric-oxide synthase when tethered to the plasma membrane calcium pump in regulating the beta-adrenergic signal in the myocardium.
In the caput epididymidis, where PMCA4 is located in the epithelium splice variant 4b was more prominent.
Title: Expression and localization of PMCA4 in rat testis and epididymis.
plasma membrane Ca2+ pump 4b/CI binds to Ca2+/calmodulin-dependent membrane-associated kinase CASK
Title: Interaction of the plasma membrane Ca2+ pump 4b/CI with the Ca2+/calmodulin-dependent membrane-associated kinase CASK.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-76189 (e-PCR)
- UniSTS:60416

D13Wox2 (e-PCR)
- UniSTS:118041

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type calcium transporter activity	IC Inferred by Curator more info	PubMed
enables P-type calcium transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables P-type calcium transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables calcium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nitric-oxide synthase binding	ISO Inferred from Sequence Orthology more info
enables nitric-oxide synthase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 2B binding	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables sodium channel regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion export	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion export	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to acetylcholine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to acetylcholine	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to epinephrine stimulus	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	ISO Inferred from Sequence Orthology more info
involved_in flagellated sperm motility	ISS Inferred from Sequence or Structural Similarity more info
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of arginine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcineurin-NFAT signaling cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cardiac muscle hypertrophy in response to stress	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of citrulline biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of nitric-oxide synthase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in neural retina development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_negative_effect nitric oxide-cGMP-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle G1/S phase transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to hydrostatic pressure	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed
involved_in urinary bladder smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in urinary bladder smooth muscle contraction	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in T-tubule	ISO Inferred from Sequence Orthology more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	EXP Inferred from Experiment more info	PubMed
is_active_in presynaptic active zone membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info
located_in sperm principal piece	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: plasma membrane calcium-transporting ATPase 4

Names: ATPase, Ca++ transporting, plasma membrane 4; plasma membrane Ca2+-ATPases 4; plasma membrane calcium ATPase; plasma membrane calcium pump

NP_001005871.1

EC 7.2.2.10

XP_008767668.1

EC 7.2.2.10

XP_038946568.1

EC 7.2.2.10

XP_038946569.1

EC 7.2.2.10

XP_038946570.1

EC 7.2.2.10

XP_038946571.1

EC 7.2.2.10

XP_038946572.1

EC 7.2.2.10

XP_038946574.1

EC 7.2.2.10

XP_063128279.1

EC 7.2.2.10

XP_063128280.1

EC 7.2.2.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005871.1 → NP_001005871.1 plasma membrane calcium-transporting ATPase 4

See identical proteins and their annotated locations for NP_001005871.1

Status: PROVISIONAL

Source sequence(s)

U15408

UniProtKB/TrEMBL

A6IC90

Related

ENSRNOP00000004078.6, ENSRNOT00000004078.8

Conserved Domains (2) summary

TIGR01517
Location:16 → 1052

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1089 → 1126

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

47708157..47807389 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039090642.2 → XP_038946570.1 plasma membrane calcium-transporting ATPase 4 isoform X2

UniProtKB/TrEMBL

A6IC89

Related

ENSRNOP00000080557.1, ENSRNOT00000112237.2

Conserved Domains (2) summary

TIGR01517
Location:16 → 1040

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1077 → 1122

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
XM_039090644.2 → XP_038946572.1 plasma membrane calcium-transporting ATPase 4 isoform X4

UniProtKB/TrEMBL

A6IC90

Conserved Domains (2) summary

TIGR01517
Location:16 → 1040

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1077 → 1114

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
XM_039090640.2 → XP_038946568.1 plasma membrane calcium-transporting ATPase 4 isoform X1

UniProtKB/Swiss-Prot

Q63127, Q63445, Q64542, Q64543, Q64544, Q64545

UniProtKB/TrEMBL

A6IC89

Related

ENSRNOP00000039880.5, ENSRNOT00000046273.6

Conserved Domains (2) summary

TIGR01517
Location:16 → 1052

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1089 → 1134

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
XM_039090646.2 → XP_038946574.1 plasma membrane calcium-transporting ATPase 4 isoform X6

UniProtKB/TrEMBL

A6IC89

Conserved Domains (2) summary

TIGR01517
Location:16 → 1052

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1089 → 1172

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
XM_039090643.2 → XP_038946571.1 plasma membrane calcium-transporting ATPase 4 isoform X3

UniProtKB/TrEMBL

A6IC90

Conserved Domains (2) summary

TIGR01517
Location:16 → 1052

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1089 → 1126

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
XM_008769446.4 → XP_008767668.1 plasma membrane calcium-transporting ATPase 4 isoform X1

See identical proteins and their annotated locations for XP_008767668.1

UniProtKB/Swiss-Prot

Q63127, Q63445, Q64542, Q64543, Q64544, Q64545

UniProtKB/TrEMBL

A6IC89

Conserved Domains (2) summary

TIGR01517
Location:16 → 1052

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1089 → 1134

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
XM_063272209.1 → XP_063128279.1 plasma membrane calcium-transporting ATPase 4 isoform X3
XM_039090641.2 → XP_038946569.1 plasma membrane calcium-transporting ATPase 4 isoform X1

UniProtKB/Swiss-Prot

Q63127, Q63445, Q64542, Q64543, Q64544, Q64545

UniProtKB/TrEMBL

A6IC89

Conserved Domains (2) summary

TIGR01517
Location:16 → 1052

ATPase-IIB_Ca; plasma-membrane calcium-translocating P-type ATPase

pfam12424
Location:1089 → 1134

ATP_Ca_trans_C; Plasma membrane calcium transporter ATPase C terminal
XM_063272210.1 → XP_063128280.1 plasma membrane calcium-transporting ATPase 4 isoform X5