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    POR2 putative porin POR2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854692, updated on 9-Dec-2024

    Summary

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    Official Symbol
    POR2
    Official Full Name
    putative porin POR2
    Primary source
    SGD:S000001376
    Locus tag
    YIL114C
    See related
    AllianceGenome:SGD:S000001376; FungiDB:YIL114C; VEuPathDB:YIL114C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable voltage-gated monoatomic anion channel activity. Involved in DNA transport and cell redox homeostasis. Located in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including VDAC1 (voltage dependent anion channel 1) and VDAC2 (voltage dependent anion channel 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See POR2 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (149143..149988, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene histidinol-phosphate transaminase Neighboring gene FG-nucleoporin NUP159 Neighboring gene mitogen-activated protein kinase tyrosine protein phosphatase SDP1 Neighboring gene Hos4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An interplay between the TOM complex and porin isoforms in the yeast Saccharomyces cerevisiae mitochondria. Antos N, et al. FEBS Lett, 2001 Jun 29. PMID 11434918
    2. Developing a genetic approach to investigate the mechanism of mitochondrial competence for DNA import. Weber-Lotfi F, et al. Biochim Biophys Acta, 2009 May. PMID 19056337, Free PMC Article
    3. Supramolecular assembly of VDAC in native mitochondrial outer membranes. Gonçalves RP, et al. J Mol Biol, 2007 Jun 1. PMID 17439818
    4. The role of yeast VDAC genes on the permeability of the mitochondrial outer membrane. Lee AC, et al. J Membr Biol, 1998 Jan 15. PMID 9435273
    5. yVDAC2, the second mitochondrial porin isoform of Saccharomyces cerevisiae. Guardiani C, et al. Biochim Biophys Acta Bioenerg, 2018 Apr. PMID 29408701

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Depletion of the porins Por1 and Por2 destabilized Ups1 and Ups2, decreased CL levels by approximately 90%, and caused loss of Ups2-dependent phosphatidylethanolamine synthesis, but did not affect Ups2-independent phosphatidylethanolamine synthesis in mitochondria.
      Title: Porin proteins have critical functions in mitochondrial phospholipid metabolism in yeast.
    2. VDAC2, the second mitochondrial porin isoform of Saccharomyces cerevisiae, has been characterized.
      Title: yVDAC2, the second mitochondrial porin isoform of Saccharomyces cerevisiae.
    3. Por2 contributes to Snf1 activation.
      Title: Mitochondrial porin Por1 and its homolog Por2 contribute to the positive control of Snf1 protein kinase in Saccharomyces cerevisiae.
    4. study has shown that both cytosol & mitochondria redox states depend on the presence of a given VDAC isoform; cytosol redox state is mediated by VDAC1, although VDAC2(POR2) has a quantitative effect; mitochondria redox state depends on both VDAC isoforms
      Title: Redox regulation of protein expression in Saccharomyces cerevisiae mitochondria: possible role of VDAC.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables porin activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated monoatomic anion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated monoatomic anion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables voltage-gated monoatomic anion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell redox homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane HDA PubMed 
    is_active_in mitochondrial outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of pore complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    putative porin POR2
    NP_012152.3
    • Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      149143..149988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179462.3 → NP_012152.3  TPA: putative porin POR2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012152.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVH3, P40478
      UniProtKB/TrEMBL
      B3LTW1, B5VKJ5, C8ZAD1, N1P9A8
      Conserved Domains (1) summary
      cd07306
      Location:6 → 280
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40478.1

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