U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    NAB2 mRNA-binding protein NAB2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852755, updated on 17-Dec-2024

    Summary

    Official Symbol
    NAB2
    Official Full Name
    mRNA-binding protein NAB2
    Primary source
    SGD:S000003090
    Locus tag
    YGL122C
    See related
    AllianceGenome:SGD:S000003090; FungiDB:YGL122C; VEuPathDB:YGL122C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA binding activity. Involved in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; poly(A)+ mRNA export from nucleus; and positive regulation of transcription by RNA polymerase III. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 56. Orthologous to human ZC3H14 (zinc finger CCCH-type containing 14). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See NAB2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (278946..280523, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Mon1p Neighboring gene ribosomal 40S subunit protein S2 Neighboring gene Gpg1p Neighboring gene DEAH-box ATP-dependent RNA helicase PRP43

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 5S rRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 7S RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables mRNA binding HDA PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables poly(A) binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables poly(A) binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ribonuclease P RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    mRNA-binding protein NAB2
    NP_011393.3
    • Nuclear Poly(A+) RNA-binding guard protein; required for nuclear mRNA export and poly(A) tail length control; stimulates RNA polymerase III transcription by enhancing TFIIIB binding to promoters; dimerizes upon RNA binding; protects mRNA against decay by nuclear exosome in a poly(A)-tail-dependent manner; involved in forming export-competent mRNPs in the nucleus; autoregulates mRNA levels; NLS binds Kap104p; protein abundance increases under DNA replication stress; related to human hnRNPs

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      278946..280523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180987.3NP_011393.3  TPA: mRNA-binding protein NAB2 [Saccharomyces cerevisiae S288C]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU26, P32505
      UniProtKB/TrEMBL
      A6ZU60
      Conserved Domains (2) summary
      pfam11517
      Location:1101
      Nab2; Nuclear abundant poly(A) RNA-bind protein 2 (Nab2)
      pfam18260
      Location:252278
      Nab2p_Zf1; Nuclear polyadenylated RNA-binding 2 protein CCCH zinc finger 1