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    MEI5 Mei5p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855982, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MEI5
    Official Full Name
    Mei5p
    Primary source
    SGD:S000006042
    Locus tag
    YPL121C
    See related
    AllianceGenome:SGD:S000006042; FungiDB:YPL121C; VEuPathDB:YPL121C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    LPH6
    Summary
    Involved in meiotic DNA recombinase assembly and reciprocal meiotic recombination. Located in condensed nuclear chromosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MEI5 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (320962..321630, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene ribonuclease T2 Neighboring gene TFIIH/NER complex subunit TFB2 Neighboring gene beclin 1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mutational analysis of Mei5, a subunit of Mei5-Sae3 complex, in Dmc1-mediated recombination during yeast meiosis. Mwaniki S, et al. Genes Cells, 2024 Aug. PMID 38924305
    2. The role of conserved amino acid residues of Sae3 in Mei5-Sae3 complex for Dmc1 assembly in meiotic recombination. Sawant P, et al. Genes Genet Syst, 2023 Jun 23. PMID 37225456
    3. The budding yeast mei5 and sae3 proteins act together with dmc1 during meiotic recombination. Tsubouchi H, et al. Genetics, 2004 Nov. PMID 15579681, Free PMC Article
    4. The budding yeast Mei5-Sae3 complex interacts with Rad51 and preferentially binds a DNA fork structure. Say AF, et al. DNA Repair (Amst), 2011 Jun 10. PMID 21543267, Free PMC Article
    5. Mei5-Sae3 stabilizes Dmc1 nucleating clusters for efficient Dmc1 assembly on RPA-coated single-stranded DNA. Wei CD, et al. Nucleic Acids Res, 2024 Oct 28. PMID 39275989, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mei5-Sae3 stabilizes Dmc1 nucleating clusters for efficient Dmc1 assembly on RPA-coated single-stranded DNA.
      Title: Mei5-Sae3 stabilizes Dmc1 nucleating clusters for efficient Dmc1 assembly on RPA-coated single-stranded DNA.
    2. The role of conserved amino acid residues of Sae3 in Mei5-Sae3 complex for Dmc1 assembly in meiotic recombination.
      Title: The role of conserved amino acid residues of Sae3 in Mei5-Sae3 complex for Dmc1 assembly in meiotic recombination.
    3. show the Mei5-Sae3 complex preferentially binds a fork-like DNA substrate to 3' overhanging DNA, single-stranded DNA or double-stranded DNA
      Title: The budding yeast Mei5-Sae3 complex interacts with Rad51 and preferentially binds a DNA fork structure.
    4. Mei5-Sae3 is a mediator of Dmc1 assembly during meiotic recombination in S. cerevisiae.
      Title: The Mei5-Sae3 protein complex mediates Dmc1 activity in Saccharomyces cerevisiae.
    5. Mei5 and Sae3 are loading factors for the RecA homolog Dmc1 recombinase and the Dmc1-Mei5-Sae3 complex is integrated onto Rad51 ensembles and plays both catalytic and structural roles in interhomolog recombination during meiosis.
      Title: A protein complex containing Mei5 and Sae3 promotes the assembly of the meiosis-specific RecA homolog Dmc1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic DNA recombinase assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mei5p
    NP_015204.1
    • Meiosis-specific protein involved in meiotic recombination; involved in DMC1-dependent meiotic recombination; forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      320962..321630 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183935.1 → NP_015204.1  TPA: Mei5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015204.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W3P6, P32489, Q02946
      UniProtKB/TrEMBL
      A6ZWD1, B3LKV3, B5VT45, C7GJ75, C8ZIQ8, G2WP60, N1NW23
      Conserved Domains (1) summary
      pfam10376
      Location:15 → 222
      Mei5; Double-strand recombination repair protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32489.2

    Gene LinkOut

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