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    CPT1 diacylglycerol cholinephosphotransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855593, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CPT1
    Official Full Name
    diacylglycerol cholinephosphotransferase
    Primary source
    SGD:S000005074
    Locus tag
    YNL130C
    See related
    AllianceGenome:SGD:S000005074; FungiDB:YNL130C; VEuPathDB:YNL130C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables diacylglycerol cholinephosphotransferase activity. Involved in CDP-choline pathway. Located in Golgi apparatus and mitochondrial outer membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 81. Orthologous to several human genes including SELENOI (selenoprotein I). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CPT1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    2
    Sequence:
    Chromosome: XIV; NC_001146.8 (379558..380831, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene ribosome biosynthesis protein KRE33 Neighboring gene Tom22p Neighboring gene Dgr1p Neighboring gene ribosylnicotinamide kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The sn-1,2-diacylglycerol cholinephosphotransferase of Saccharomyces cerevisiae. Nucleotide sequence, transcriptional mapping, and gene product analysis of the CPT1 gene. Hjelmstad RH, et al. J Biol Chem, 1990 Jan 25. PMID 2153142
    2. The role of phosphatidylcholine biosynthesis in the regulation of the INO1 gene of yeast. Griac P, et al. J Biol Chem, 1996 Oct 11. PMID 8810347
    3. Mutants of Saccharomyces cerevisiae defective in sn-1,2-diacylglycerol cholinephosphotransferase. Isolation, characterization, and cloning of the CPT1 gene. Hjelmstad RH, et al. J Biol Chem, 1987 Mar 15. PMID 3029130
    4. Phosphatidylcholine biosynthesis in Saccharomyces cerevisiae. Regulatory insights from studies employing null and chimeric sn-1,2-diacylglycerol choline- and ethanolaminephosphotransferases. McMaster CR, et al. J Biol Chem, 1994 Nov 11. PMID 7961735
    5. Phosphatidylcholine biosynthesis via the CDP-choline pathway in Saccharomyces cerevisiae. Multiple mechanisms of regulation. McMaster CR, et al. J Biol Chem, 1994 May 20. PMID 8182083

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables diacylglycerol cholinephosphotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diacylglycerol cholinephosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol cholinephosphotransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, for other substituted phosphate groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in CDP-choline pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in CDP-choline pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylcholine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    diacylglycerol cholinephosphotransferase
    NP_014269.4
    • Cholinephosphotransferase; required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription; CPT1 has a paralog, EPT1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      379558..380831 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182968.3 → NP_014269.4  TPA: diacylglycerol cholinephosphotransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014269.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W152, P17898
      UniProtKB/TrEMBL
      A6ZRV3, B3LNY7, C8ZGA0
      Conserved Domains (1) summary
      COG5050
      Location:2 → 393
      EPT1; sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases [Lipid metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17898.3

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