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    SEC10 exocyst subunit SEC10 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850863, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SEC10
    Official Full Name
    exocyst subunit SEC10
    Primary source
    SGD:S000004156
    Locus tag
    YLR166C
    See related
    AllianceGenome:SGD:S000004156; FungiDB:YLR166C; VEuPathDB:YLR166C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in Golgi to plasma membrane transport and exocytosis. Located in cellular bud neck and mating projection tip. Part of exocyst. Orthologous to human EXOC5 (exocyst complex component 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SEC10 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (495429..498044, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene protein SHH4 Neighboring gene pseudouridine synthase PUS5 Neighboring gene ubiquitin-ribosomal 40S subunit protein S31 fusion protein Neighboring gene Ups2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exocyst is involved in cystogenesis and tubulogenesis and acts by modulating synthesis and delivery of basolateral plasma membrane and secretory proteins. Lipschutz JH, et al. Mol Biol Cell, 2000 Dec. PMID 11102522, Free PMC Article
    2. Conservation of helical bundle structure between the exocyst subunits. Croteau NJ, et al. PLoS One, 2009. PMID 19214222, Free PMC Article
    3. Exo84p is an exocyst protein essential for secretion. Guo W, et al. J Biol Chem, 1999 Aug 13. PMID 10438536
    4. Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae. TerBush DR, et al. J Cell Biol, 1995 Jul. PMID 7615633, Free PMC Article
    5. The rab exchange factor Sec2p reversibly associates with the exocyst. Medkova M, et al. Mol Biol Cell, 2006 Jun. PMID 16611746, Free PMC Article

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in Golgi to plasma membrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Golgi to plasma membrane transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in Golgi to plasma membrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cellular bud neck HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of exocyst IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exocyst IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mating projection tip HDA PubMed 

    General protein information

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    Preferred Names
    exocyst subunit SEC10
    NP_013267.1
    • Essential 100kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      495429..498044 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182053.1 → NP_013267.1  TPA: exocyst subunit SEC10 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013267.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYH2, P87329, Q06245
      UniProtKB/TrEMBL
      A7A159, B5VN85, C7GIV8, C8ZDD9, G2WJ01
      Conserved Domains (1) summary
      pfam07393
      Location:120 → 858
      Sec10; Exocyst complex component Sec10
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06245.1

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