CAT2 carnitine O-acetyltransferase CAT2 [Saccharomyces cerevisiae S288C] - Gene

Summary

Go to the top of the page Help

Official Symbol: CAT2
Official Full Name: carnitine O-acetyltransferase CAT2
Primary source: SGD:S000004506
Locus tag: YML042W
See related: AllianceGenome:SGD:S000004506; FungiDB:YML042W; VEuPathDB:YML042W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: YCAT
Summary: Enables carnitine O-acetyltransferase activity. Involved in carnitine metabolic process. Located in mitochondrion and peroxisome. Human ortholog(s) of this gene implicated in Alzheimer's disease; congenital myasthenic syndrome 6; and neurodegeneration with brain iron accumulation. Orthologous to several human genes including CRAT (carnitine O-acetyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See CAT2 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (192788..194800)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

that carnitine protects cells from oxidative and organic acid stress, while CAT2 contributes to the response to oxidative stress.
Title: Carnitine and carnitine acetyltransferases in the yeast Saccharomyces cerevisiae: a role for carnitine in stress protection.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables carnitine O-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carnitine O-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables carnitine O-acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in carnitine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in carnitine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: carnitine O-acetyltransferase CAT2

NP_013670.1

EC 2.3.1.7

Carnitine acetyl-CoA transferase; present in both mitochondria and peroxisomes; transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

192788..194800

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182400.1 → NP_013670.1 TPA: carnitine O-acetyltransferase CAT2 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013670.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZD3, P32796

UniProtKB/TrEMBL

G2WK13, N1P0W9

Conserved Domains (1) summary

pfam00755
Location:74 → 657

Carn_acyltransf; Choline/Carnitine o-acyltransferase