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    FAR1 cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853283, updated on 9-Dec-2024

    Summary

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    Official Symbol
    FAR1
    Official Full Name
    cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1
    Primary source
    SGD:S000003693
    Locus tag
    YJL157C
    See related
    AllianceGenome:SGD:S000003693; FungiDB:YJL157C; VEuPathDB:YJL157C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cyclin-dependent protein serine/threonine kinase inhibitor activity. Involved in chemotropism; maintenance of protein location in nucleus; and mitotic cell cycle G1 arrest in response to pheromone. Located in cytoplasm; mating projection tip; and nucleus. Part of Cdc24p-Far1p-Gbetagamma complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See FAR1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (123836..126328, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene heat shock protein HSP150 Neighboring gene Cis3p Neighboring gene Ssy5p Neighboring gene fructose-2,6-bisphosphatase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phosphorylation of FAR1 in response to alpha-factor: a possible requirement for cell-cycle arrest. Chang F, et al. Mol Biol Cell, 1992 Apr. PMID 1498364, Free PMC Article
    2. FAR1 and the G1 phase specificity of cell cycle arrest by mating factor in Saccharomyces cerevisiae. McKinney JD, et al. Mol Cell Biol, 1995 May. PMID 7739534, Free PMC Article
    3. FAR1 is required for oriented polarization of yeast cells in response to mating pheromones. Valtz N, et al. J Cell Biol, 1995 Nov. PMID 7490290, Free PMC Article
    4. Switch-like Transitions Insulate Network Motifs to Modularize Biological Networks. Atay O, et al. Cell Syst, 2016 Aug. PMID 27453443, Free PMC Article
    5. FAR1 is required for posttranscriptional regulation of CLN2 gene expression in response to mating pheromone. Valdivieso MH, et al. Mol Cell Biol, 1993 Feb. PMID 8423774, Free PMC Article

    See all (127) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This papers suggests that Far1 engages the cyclin-Cdk complex in a way that disrupts multiple distinct functions, including both substrate docking and kinase activity but perhaps also others such as Cks1-mediated processivity.
      Title: Regulation of cyclin-substrate docking by a G1 arrest signaling pathway and the Cdk inhibitor Far1.
    2. Studied FAR1 overexpression, which not only coordinately increases RNA and protein accumulation, but induces strong transcriptional remodeling.
      Title: Overexpression of Far1, a cyclin-dependent kinase inhibitor, induces a large transcriptional reprogramming in which RNA synthesis senses Far1 in a Sfp1-mediated way.
    3. Cln3 must overcome Far1 to trigger Cln-Cdc28 activation, which then turns on transcription; a second threshold is required together with the Cln3/Far1 threshold for carbon source modulation of protein content per cell at the onset of DNA replication
      Title: A cell sizer network involving Cln3 and Far1 controls entrance into S phase in the mitotic cycle of budding yeast.
    4. Gbetagamma not only targets Far1p to the correct site but may also trigger a conformational change in Far1p that is required for its ability to activate Cdc24p in vivo
      Title: Site-specific regulation of the GEF Cdc24p by the scaffold protein Far1p during yeast mating.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chemotropism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of protein location in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle G1 arrest in response to pheromone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to pheromone triggering conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cdc24p-Far1p-Gbetagamma complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Cdc24p-Far1p-Gbetagamma complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1
    NP_012378.1
    • CDK inhibitor and nuclear anchor; during the cell cycle Far1p sequesters the GEF Cdc24p in the nucleus; phosphorylation by Cdc28p-Cln results in SCFCdc4 complex-mediated ubiquitin-dependent degradation, releasing Cdc24p for export and activation of GTPase Cdc42p; in response to pheromone, phosphorylation of Far1p by MAPK Fus3p results in association with, and inhibition of Cdc28p-Cln, as well as Msn5p mediated nuclear export of Far1p-Cdc24p, targeting Cdc24p to polarity sites

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      123836..126328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181590.1 → NP_012378.1  TPA: cyclin-dependent protein serine/threonine kinase inhibiting protein FAR1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012378.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW30, P21268
      UniProtKB/TrEMBL
      G2WGL6
      Conserved Domains (1) summary
      smart00184
      Location:202 → 251
      RING; Ring finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21268.2

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