PHS1 enoyl-CoA hydratase PHS1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PHS1
Official Full Name: enoyl-CoA hydratase PHS1
Primary source: SGD:S000003633
Locus tag: YJL097W
See related: AllianceGenome:SGD:S000003633; FungiDB:YJL097W; VEuPathDB:YJL097W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables 3-hydroxyacyl-CoA dehydratase activity. Involved in fatty acid elongation; sphingolipid biosynthetic process; and vacuolar transport. Located in endoplasmic reticulum membrane and fungal-type vacuole. Used to study cancer. Human ortholog(s) of this gene implicated in congenital myopathy. Orthologous to human HACD1 (3-hydroxyacyl-CoA dehydratase 1) and HACD2 (3-hydroxyacyl-CoA dehydratase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PHS1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (245591..246244)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The enzyme kinetics study implicated the direct involvement of the Arg83 and Gly152 residues in the catalytic process.
Title: Identification of residues important for the catalysis, structure maintenance, and substrate specificity of yeast 3-hydroxyacyl-CoA dehydratase Phs1.
Phs1 is a 3-hydroxyacyl-CoA dehydratase involved in very long-chain fatty acid elongation
Title: Membrane topology and essential amino acid residues of Phs1, a 3-hydroxyacyl-CoA dehydratase involved in very long-chain fatty acid elongation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 3-hydroxyacyl-CoA dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 3-hydroxyacyl-CoA dehydratase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables enoyl-CoA hydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid elongation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid elongation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sphingolipid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vacuolar transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in very long-chain fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in fungal-type vacuole	HDA more info	PubMed
located_in fungal-type vacuole	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type vacuole membrane	HDA more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear outer membrane-endoplasmic reticulum membrane network	HDA more info	PubMed
located_in vacuolar membrane	IEA Inferred from Electronic Annotation more info
located_in vacuole	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: enoyl-CoA hydratase PHS1

NP_012438.1

EC 4.2.1.134

Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane; involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

245591..246244

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181530.1 → NP_012438.1 TPA: enoyl-CoA hydratase PHS1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012438.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VW87, P40857

UniProtKB/TrEMBL

A6ZPM7, B3LQ16, B5VL76, C7GR17, C8ZBB7, G2WGS1, N1NZS6

Conserved Domains (1) summary

COG5198
Location:1 → 217

Ptpl; Protein tyrosine phosphatase-like protein (contains Pro instead of catalytic Arg) [General function prediction only]