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    PTH1 aminoacyl-tRNA hydrolase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856596, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PTH1
    Official Full Name
    aminoacyl-tRNA hydrolase
    Primary source
    SGD:S000001232
    Locus tag
    YHR189W
    See related
    AllianceGenome:SGD:S000001232; FungiDB:YHR189W; VEuPathDB:YHR189W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables aminoacyl-tRNA hydrolase activity. Involved in mitochondrial translation. Located in mitochondrion. Orthologous to human PTRH1 (peptidyl-tRNA hydrolase 1 homolog). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PTH1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (484028..484600)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene Elongator subunit IKI1 Neighboring gene GPI-anchor transamidase subunit GPI16 Neighboring gene bifunctional farnesyl-diphosphate farnesyltransferase/squalene synthase Neighboring gene Ctf8p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Enzymatic hydrolysis of N-substituted aminoacyl transfer ribonucleic acid in yeast. Jost JP, et al. J Biol Chem, 1969 Nov 10. PMID 4981785
    2. New protein functions in yeast chromosome VIII. Ouzounis C, et al. Protein Sci, 1995 Nov. PMID 8563640, Free PMC Article
    3. Peptidyl-tRNA hydrolase from Sulfolobus solfataricus. Fromant M, et al. Nucleic Acids Res, 2003 Jun 15. PMID 12799450, Free PMC Article
    4. Membrane rafts are involved in intracellular miconazole accumulation in yeast cells. François IE, et al. J Biol Chem, 2009 Nov 20. PMID 19783660, Free PMC Article
    5. Peptidyl-tRNA hydrolase in Bacillus subtilis, encoded by spoVC, is essential to vegetative growth, whereas the homologous enzyme in Saccharomyces cerevisiae is dispensable. Menez J, et al. Mol Microbiol, 2002 Jul. PMID 12100553

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aminoacyl-tRNA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminoacyl-tRNA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aminoacyl-tRNA hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA hydrolase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    aminoacyl-tRNA hydrolase
    NP_012059.3
    • One of two mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium; see also PTH2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      484028..484600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179320.3 → NP_012059.3  TPA: aminoacyl-tRNA hydrolase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012059.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLD7, P38876
      UniProtKB/TrEMBL
      A6ZT95, B3LSV0, C7GRL1, C8Z9Y8, G2WFR2, N1P9I3
      Conserved Domains (1) summary
      TIGR00447
      Location:6 → 190
      pth; aminoacyl-tRNA hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38876.1

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